【摘要】 目的:应用相位对比磁共振成像(PC-MRI)技术测量中单纯性脑缺血灶血流动力学参数,探讨单纯性脑缺血灶血流动力学变化的模式。方法:对单纯性脑缺血灶患者进行常规头颅MRI扫描,筛选出正常组12例、轻度脑缺血组16例和明显脑缺血组13例,3组均行双侧PCMRI扫描,利用工作站上QFLOW软件进行后处理,获得1次心动周期内双侧MCA的时相一流速曲线及相关血流动力学参数;记录双侧MCA的血管断面面积、峰值流速(PV)、平均流速(MV)、平均流量(MF)。采用SPSS17.0统计软件比较3组间血流动力学各参数的差异。结果:3组间双侧MCA血管断面面积、MV、MF及右侧MCAPV的单向方差分析比较均有统计学差异(P值均<0.05)。慢性脑缺血患者双侧MCA的时相一流速曲线较正常中老年人收缩期波峰变低、变钝、变宽,舒张期和收缩期两波峰连线变平。结论:PC-MRI可反映单纯性脑缺血灶患者脑动脉血流动力学变化模式的差异。更多还原

【Abstract】 Objective To investigate the hemodynamic changes of simple cerebral ischemia foci by using phase contrast magnetic resonance imaging (PC-MRI) to measure the hemodynamic parameters of simple cerebral ischemia foci.Methods The patients with idiopathic focal cerebral ischemia for regular head MRI scans,select normal group of 12 cases,16 cases and mild cerebral ischemia group was obviously cerebral ischemia group of 13 cases,3 groups were performed bilateral PCMRI scan,using the workstation QFLOW post-processing software,get one cardiac cycle in bilateral MCA phase velocity curve and the associated hemodynamic parameters;The vascular sectional area,peak flow rate (PV),average flow rate (MV),and average flow rate (MF) of bilateral MCA were recorded.SPSS17.0 statistical software was used to compare the differences of hemodynamic parameters among 3 groups.Results There were statistically significant differences between the three groups in the one-way ANOVA of the area,MV,MF and the MCAPV on the right (all P < 0.05).The time-phase velocity curve of bilateral MCA in patients with chronic cerebral ischemia was lower,obtuse and wider than that in normal middle-aged and elderly patients with systolic crest,and the line between diastolic and systolic crest was flattened.Conclusion PCMRI can reflect the difference of cerebral arterial blood flow mechanics in patients with simple cerebral ischemia.更多还原