【摘要】 目的探究血清腺苷脱氨酶(ADA)、总氧化态(TOS)、糖类抗原153(CA153)联合检测对肺结核的诊断价值。方法选取本院2018年6月至2021年3月76例肺结核患者为肺结核组,选取同期63例非结核呼吸系统疾病患者为对照组。比较两组血清ADA、TOS、CA153水平,分析血清ADA、TOS、CA153水平与肺结核发生的关系及对肺结核的诊断价值,参照《实用结核病学》将患者分为重症组及轻症组,比较两组的血清ADA、TOS、CA153水平,分析各指标联合检测对肺结核严重程度的评估价值。结果肺结核组的血清ADA、TOS、CA153水平均高于对照组,差异均有统计学意义(P<0.05)。血清ADA≥28.64 U/L、CA153≥13.51 U/mL是影响肺结核发生的危险因素(P<0.05)。血清ADA、TOS、CA153水平联合检测诊断肺结核的AUC为0.827,大于各指标单独检测(P<0.05)。重症组血清ADA、TOS、CA153水平均高于轻症组,差异均有统计学意义(P<0.05)。血清ADA、TOS、CA153水平联合检测评估肺结核严重程度的AUC为0.765,大于各指标单独检测(P<0.05)。结论血清ADA、TOS、CA153水平可作为肺结核及病情严重程度诊断评估的依据,且这3个指标联合检测具有较高的诊断价值,更利于临床诊断。更多还原

【Abstract】 Objective To explore the diagnostic value of serum adenosine deaminase（ADA combined with total oxidation state（TOS）and carbohydrate antigen 153（CA153）in tuberculosis. Methods A total of 76 patients with tuberculosis in the hospital were enrolled as the tuberculosis group from June 2018 to March 2021,while other 63 patients with non-tuberculous respiratory diseases during the same period were enrolled as the control group. The levels of serum ADA,TOS and CA153 between the two groups were compared. Their relationship with tuberculosis and diagnostic value for tuberculosis were analyzed. The levels of serum ADA,TOS and CA153 between the severe group and mild group were compared. The evaluation value of their combination for tuberculosis severity was analyzed. Results The levels of serum ADA,TOS and CA153 in the tuberculosis group were higher than those in the control group（P<0.05）. Serum ADA ≥ 28.64 U/L and CA153 ≥ 13.51 U/mL are risk factors affecting the occurrence of tuberculosis（P<0.05）. The AUC of serum ADA combined with TOS and CA153 in the diagnosis of tuberculosis（0.827）was greater than that of single indicator（P<0.05）. The levels of serum ADA,TOS and CA153 in the severe group were higher than those in the mild group（P<0.05）. The AUC of serum ADA combined with TOS and CA153 in the assessment oftuberculosis severity was 0.765,which was greater than the detection of single indicator alone（P<0.05）.Conclusion The serum ADA,TOS and CA153 levels can be applied as the basis in the diagnostic and evaluation of tuberculosis and the disease severity,and the combined detection of the three indicators has high diagnostic value and is more conducive to clinical diagnosis.更多还原