【摘要】 目的探讨年轻男性急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)手术前后血清心型脂肪酸结合蛋白(HFABP)、α-颗粒膜蛋白-140(GMP-140)、凝集蛋白-1(ITLN-1)水平变化情况及临床意义。方法选取2017年3月至2020年2月南阳市中心医院98例年轻男性AMI患者作为研究组,另选取30例同年龄段健康年轻男性作为对照组。检测并比较两组血清HFABP、GMP-140、ITLN-1及心肌损伤指标[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)]水平。结果研究组术前HFABP、GMP-140、CK-MB、cTnT水平高于术后及对照组,差异有统计学意义(P<0.05);研究组术前HFABP、GMP-140与CK-MB、cTnT呈正相关,ITLN-1与CK-MB、cTnT呈负相关(P<0.05);随着BMI、高脂血症、置入支架数目、支架直径、手术前后血清HFABP、GMP-140、CK-MB、c TnT水平增加、血清ITLN-1水平降低,年轻男性AMI患者PCI术后发生短期心血管事件的风险升高(P<0.05)。结论年轻男性AMI患者血清HFABP、GMP-140升高,血清ITLN-1水平降低,PCI手术前后各指标改变与短期心血管事件的发生有关。更多还原

【Abstract】 Objective To investigate the changes of serum heart-type fatty acid binding protein（HFABP）,α-Granule membrane protein-140（GMP-140）,intelectin-1（ITLN-1）levels before and after percutaneous coronary intervention（PCI）in young male patients with acute myocardial infarction（AMI）,and to analyze the clinical significance of the changes. Methods Ninety-eight young male AMI patients from Nanyang Central Hospital were selected as the research group,and 30 healthy young men of the same age group were selected as the control group. The levels of serum HFABP,GMP-140,ITLN-1 and myocardial injury indexes[creatine kinase isoenzyme（CK-MB）and cardiac troponin T（cTnT）]were detected and compared between the two groups. Results The levels of HFABP,GMP-140,CK-MB and cTnT before surgery in the research group were higher than those after surgery and in the control group（P<0.05）. In the research group,HFABP and GMP-140 were positively correlated with CK-MB and cTnT before surgery,and ITLN-1 was negatively correlated with CK-MB and cTnT（P<0.05）. With the increase of BMI,hyperlipidemia,number ofstents inserted,diameter of stents,increase in serum HFABP,GMP-140,CK-MB,c Tn T levels before and after surgery,and decrease in serum ITLN-1 levels,short-term development of young male AMI patients after PCI The risk of cardiovascular events increased,and the difference was statistically significant（P<0.05）. The area under the curve（AUC）of postoperative serum HFABP,GMP-140,ITLN-1 and myocardial injury indexes predicting short-term cardiovascular events in young male patients with AMI after PCI were all above 0.7. The AUC of the joint prediction was the largest,0.891,and the best prediction sensitivity and specificity were80.00% and 90.36%,respectively. Conclusion The serum HFABP and GMP-140 in young male patients with AMI increased,and the level of ITLN-1 decreased. The changes in indicators before and after PCI surgery are related to the occurrence of short-term cardiovascular events and have high application value in predicting the occurrence of short-term cardiovascular events.更多还原