【摘要】 目的系统追踪分析1例人类免疫缺陷病毒(HIV)和梅毒窗口期合并感染献血者临床表现、诊断和治疗效果。方法对一名HIV和梅毒窗口期合并感染并在早期接受青霉素和抗逆转录病毒治疗(ART)的42岁献血者进行11次系统追踪研究,比较分析免疫学方法和核酸检测(NAT)方法检测结果,临床疗效。结果献血者经单人份核酸筛查(ID-NAT)检出HIV阳性,酶联免疫吸附梅毒抗体试剂1(抗-TP1)检出抗-TP阳性。献血后第6天,4代抗-HIV酶联免疫吸附试验(ELISA)和化学发光免疫分析(CLIA)试剂检测结果阳性;献血后第117天,除6人份混合(6-MP)NAT外,所有NAT检测HIVRNA均呈阳性反应;献血后3个月内,HIV RNA病毒载量急剧下降,献血后246天降至检出限以下;献血后403天,外周血中仍可检测到HIV-1 DNA。献血后80天,甲苯胺红未加热血清试验(TRUST)检测呈阴性。结论梅毒和HIV窗口期共感染时,HIV感染的窗口期相对延长,检测试剂敏感性无显著改变,对两种病原体的治疗效果也无显著影响。更多还原

【Abstract】 Objective To follow up the study of 1 case of concurrent infection with human immunodeficiency virus（HIV）and syphilis during the window period,and to analysis the clinical manifestations,diagnosis,and treatment effects of a blood donor at very early stages. Methods One longitudinal study was conducted in a 42-year-old blood donor who was concurrently infected with syphilis and HIV. This blood donor was treated with a penicillin-based regimen and early antiretroviral therapy（ART）. Immunological and NAT methods were comparatively analyzed. Results Microbiological analysis using a 4 th generation anti-HIV ELISA and CLIA indicated a positive signal on the 6 th day after blood donation. All NAT tests for HIV RNA were reactive except for six pooled samples on 117 th day after blood donation. The HIV viral load declined more than 4-log in copies per milliliter over 3 months,until reaching non-detectable levels on the 246 th day after更多还原