【摘要】 目的探究补体C1q肿瘤坏死因子相关蛋白3(CTRP3)、脂蛋白a(Lp(a))对冠心病合并糖尿病经皮冠状动脉介入治疗(PCI)术后支架内再狭窄(ISR)的预测价值。方法选取本院86例冠心病合并糖尿病患者,均行PCI术治疗,根据随访6个月是否发生ISR分为ISR组(15例)与无ISR组(71例)。检测血清CTRP3、Lp(a)水平,分析两者对PCI术后ISR的预测价值。结果 ISR组血清CTRP3、Lp(a)高于无ISR组,差异有统计学意义(P<0.05);血清CTRP3与HbA1c、SYNTAX积分呈负相关,Lp(a)与HbA1c、SYNTAX积分呈正相关,均是PCI术后ISR的重要影响因素(P<0.05);血清CTRP3、Lp(a)联合预测PCI术后ISR的AUC为0.882,95%CI为0.794～0.941,敏感度为93.33%,特异度为81.69%,优于两者单独预测(P<0.05)。结论血清CTRP3、Lp(a)与冠心病合并糖尿病患者病情联系紧密,联合检测可作为预测PCI术后ISR的潜在途径。更多还原

【Abstract】 Objective To explore the predictive value of complement C1 q/tumor necrosis factor related protein 3(CTRP3)and lipoprotein a(Lp(a))for in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)for coronary heart disease complicated with diabetes. Methods A total of 86 patients with coronary heart disease and diabetes mellitus in our hospital were selected for PCI treatment. According to whether ISR occurred during the 6-month follow-up,they were divided into the ISR group(15 cases)and the no ISR group(71 cases). The serum CTRP3 and Lp(a)levels were detected,and their predictive value for ISR after PCI was analyzed. Results Serum CTRP3 and Lp(a)in the ISR group were higher than those in the no ISR group(P<0.05). Serum CTRP3 was negatively correlated with HbA1 c and SYNTAX scores,and Lp(a)was positively correlated with HbA1 c and SYNTAX scores,both are important influencing factors of ISR after PCI(P<0.05). The AUC of ISR after PCI predicted by the combination of serum CTRP3 and Lp(a)was 0.882. The 95% CI ranged from 0.794 to 0.941,the sensitivity was 93.33%,and the specificity was81.69%,which was better than the two predictions alone(P<0.05). Conclusion Serum CTRP3 and Lp(a)are closely related to the condition of patients with coronary heart disease complicated with diabetes. Combined detection can be used as a potential way to predict ISR after PCI.更多还原