【摘要】 目的探究T细胞亚群、白介素-6（IL-6）及白介素-10（IL-10）在支气管哮喘患儿治疗中的变化。方法选取2018年8月至2020年1月本院收治的102支气管哮喘的患儿作为研究对象,根据治疗方法不同分为研究组（孟鲁司特联合布地奈德治疗52例）和基础组（布地奈德治疗50例）,比较两组治疗效果,比较两组T淋巴细胞亚群水平,IL-6、IL-10水平以及用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、最大呼气流量（PEF）等肺功能指标的水平。结果研究组治疗总有效率（96.15%）高于基础组治疗总有效率（84.00%）,差异具有统计学意义（P<0.05）。治疗后,两组CD₃⁺、CD₄⁺、CD₄⁺/CD₈⁺水平升高,CD₈⁺水平下降,研究组变化程度明显高于基础组,差异具有统计学意义（P<0.05）。用药后,两组IL-6含量下降,IL-10含量上升,研究组IL-6、IL-10变化水平较基础组高,差异具有统计学意义（P<0.05）。用药后,两组FVC、PEF、FEV1等肺功能指标数值均有不同程度的上升,研究组上升幅度明显高于基础组,差异具有统计学意义（P<0.05）。结论孟鲁司特联合布地奈德治疗支气管哮喘临床疗效显著,能够有效改善患儿肺功能肺功能,提高CD₃⁺、CD₄⁺、CD₄⁺/CD₈⁺以及IL-10水平,降低CD₈⁺、IL-6水平。更多还原

【Abstract】 Objective To explore the changes of T cell subsets,interleukin-6（IL-6）and interleukin-10（IL-10）in the treatment of children with bronchial asthma. Method 102 children with bronchial asthma admitted to this hospital from August 2018 to January 2020 were selected. According to different treatment methods,they were divided into a study group（Montelukast combined with budesonide,52 cases）and a basic group（budesonide,50 cases）. The treatment effects,T lymphocyte subgroup levels,the levels of IL-6,IL-10,and the levels of lung function indexes such as forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）and peak expiratory flow（PEF）were compared between the two groups. Result The total effective rate of treatment between the study group（96.15%）and the basic group（84.00%）were compared,and the difference was statistically significant（P<0.05）. After treatment,the levels of CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺in the two groups increased,and the level of CD₈⁺decreased. The degree of change in the study group was significantly higher than that in the basic group,and the difference was statistically significant（P<0.05）. After medication,the level of IL-6 in the two groups decreased and the level of IL-10 increased. The changes in levels of IL-6 and IL-10 in the study group were higher than those in the basic group,and the difference was statistically significant（P<0.05）. After medication,the values of lung function indexes such as FVC,PEF,FEV1 and so on in the two groups increased to varying degrees,and the increase in the study group was significantly higher than that of the basic group,and the difference was statistically significant（P<0.05）. Conclusion Montelukast combined with budesonide has a significant clinical effect in the treatment of bronchial asthma,which can effectively improve the lung function of children,increase CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺and IL-10 levels,and reduce CD₈⁺and IL-6 levels.更多还原