【摘要】 目的:了解川崎病患者的临床用药特点和规律,促进临床合理用药。方法:采用回顾性研究的方法,提取我院2019年10月–12月诊断为川崎病的住院患者病历信息,共计178例,对其临床用药情况进行统计分析。结果:丙种球蛋白不同给药时机下（早期、常规、晚期）三组间无统计学差异（P> 0.05）;丙种球蛋白不同给药方式(1 g·kg^-1·d^-1,2 d;2 g·kg^-1·d^-1,1 d)下患者体温恢复正常情况两组间无统计学差异（P> 0.05）。急性期阿司匹林不同给药剂量下(80～120 mg·kg^-1·d^-1、30～50 mg·kg^-1·d^-1、<30 mg·kg^-1·d^-1)三组患者体温恢复情况无统计学差异（P> 0.05）。丙种球蛋白无反应患者采用激素冲击治疗24 h的退热比例（76.9%）高于再次给予丙种球蛋白治疗组（39.3%）,差异具有统计学意义（P <0.05）。结论:川崎病患者应尽早给予丙种球蛋白治疗,给药方式推荐2 g·kg^-1·d^-1,1 d,考虑一次性输注的不良反应可分2 d给药。急性期阿司匹林剂量推荐30～50 mg·kg^-1·d^-1或更低。考虑到退热效果和经济性,丙种球蛋白无反应患者首推激素治疗。更多还原

【Abstract】 Objective: To understand the characteristics and regularities of clinical medication in patients with Kawasaki disease and promote the rational drug use. Methods: A total of 178 patients diagnosed with Kawasaki disease in our hospital from October 2019 to December 2019 were retrospectively selected, medication of them were analyzed and summarized. Results: There was no statistical difference among the three groups（P > 0.05） under different administration time of gamma globulin（early, conventional and late）; There was no significant difference in the body temperature recovery of patients with Kawasaki disease between two groups（P > 0.05） under different administraion of gamma globulin(1 g·kg^-1·d^-1, 2 d; 2 g·kg^-1·d^-1, 1 d). There was no significant difference in the recovery of body temperature among the three groups(80 – 120 mg·kg^-1·d^-1, 30 – 50 mg·kg^-1·d^-1, < 30 mg·kg^-1·d^-1) under different doses of aspirin in acute stage（P > 0.05）. The antipyretic rate in 24 h of patients with no response to gamma globulin given impact therapy of hormone was 76.9%, which was higher than 39.3% in the gamma globulin group. Conclusion: Intravenous injection of gamma globulin should be given as soon as possible for patients with Kawasaki disease. The recommended regimen of gamma globulin was 2 g·kg^-1·d^-1 for 1 d, which also could be given in two days for patients who might develop adverse reaction to one-time infusion. The recommended dose of aspirin in acute stage was 30 – 50 mg·kg^-1·d^-1 or lower. Considering the antipyretic effect and economy, hormone therapy was recommended as the first choice for patients with no response to gamma globulin.更多还原