【摘要】 目的:了解我院耐药结核病患者使用利奈唑胺所致不良反应的发生特点和规律,为临床合理用药提供参考。方法:收集整理2015年1月–2020年6月我院耐药结核病患者使用利奈唑胺后出现相关ADR的数据资料,共计纳入89例患者,108例次ADR,对病历和随访资料进行统计分析。结果:89例患者中,男性65例(73.03%),女性24例(26.97%),19～59岁之间70例;ADR主要表现为周围神经炎(35例次)、视神经炎(12例次)、血液系统不良反应(32例次),经停药或对症处理后大多患者好转。结论:长期应用利奈唑胺需警惕严重ADR的发生,并加强监测,当ADR发生时及时予以治疗,确保患者用药安全。更多还原

【Abstract】 Objective: To investigate the linezolid-induced adverse drug reactions(ADRs) in drug-resistant tuberculosis patients in our hospital, and provide references for rational drug use. Methods: A total of 89 patients(108 cases) of linezolidinduced ADRs among drug-resistant tuberculosis inpatients in our hospital from January 2015 to June 2020 were collected and their data were statistically analyzed. Results: Among 89 patients, there were 65 males(73.03%) and 24 females(26.97%). 70 patients were within 19 – 59 years old. The main manifestations of linezolid-induced ADRs were peripheral neuritis(35 cases), optic neuritis(12 cases) and ADRs in the blood system(32 cases). Most patients improved after symptomatic treatment or withdrawal of linezolid. Conclusion: The occurrence of severe ADR induced by linezolid should be alert to in long-term use of linezolid, which should be monitored and dealt with timely.When ADR occurred, it should be treated in time to ensure the safety of drug use.更多还原