【摘要】 目的探讨广西北海市人民医院住院的甲亢性周期性麻痹（TPP）患者的临床特点,提升医师对该类患者的认识。方法收集北海市人民医院2013—2019年住院的TPP患者42例,甲状腺功能正常低钾性周期性麻痹患者55例,观察患者的肌力、电解质等资料,并进行比较分析。结果 TPP好发于20～30岁,且年龄跨度大,夏季TPP患者发作最多（35.1%,15/42）。与非甲亢性低钾性周期性麻痹相比,TPP患者的年龄、HCO₃^-均低于甲状腺功能正常组,脉搏高于甲状腺功能正常组,其余指标比较差异无统计学意义。首次诊断甲亢患者22例,非首次诊断甲亢患者20例,2组之间比较差异无统计学意义。TPP患者的血钾相关分析显示,血钾与肌力呈正相关,与FT3呈负相关。利用ROC曲线检测脉搏在诊断TPP的效能,AUC为0.794,相对应的最佳界值为87次/min。结论 TPP患者夏季多见,其血钾与肌力呈正相关,与FT3呈负相关,而脉搏是筛查TPP一个简单有效的工具。TPP患者应同时治疗甲亢及低血钾。更多还原

【Abstract】 Objective To investigate the clinical characteristics of hospitalized patients with thyrotoxic periodic paralysis（TPP） in Beihai City, and improve physicians’ knowledge of the disease. Methods Forty-two TPP patients and 55 normothyroidic patients with hypokalemic periodic paralysis（HPP） admitted to Beihai Municipal People’ s Hospital between 2013 and 2019 were included in the study. The data of muscle strength and electrolytes were deter-mined and compared. Results TPP frequently occurred in patients aged between 20 and 30 years old, with a wide range of patient age, and the frequency of TPP attack was the highest in summer（35.1%, 15/42）. Compared with non-thyrotoxic HPP patients, the age and HCO₃^-in TPP patients were lower, and the pulse rate was higher. The other indicators showed no statistical significant differences between groups. There were 22 cases of newly diagnosed hyperthy-roidism and 20 cases of non-newly diagnosed hyperthyroidism, which was not statistically different between the two groups. Correlation analysis of serum potassium in TPP patients showed that serum potassium was positively correlated with muscle strength and negatively correlated with FT3. ROC curve was used to examine the performance of pulse rate in diagnosing TPP, yielding an AUC of 0.794 that corresponded to an optimal cut-off of 87 beats/min. Conclusion TPP frequently occurs in summer. Serum potassium is positively correlated with muscle strength and negatively corre-lated with FT3 in TPP patients. Pulse is a simple and effective indicator for TPP screening. TPP patients should be treated simultaneously for hyperthyroidism and hypokalemia.更多还原