【摘要】 目的分析维生素D对3～7岁哮喘患儿的辅助治疗效果。方法以262例哮喘患儿为研究对象,将其分别按年龄、性别和病情状况进行分层后,随机分为维生素D治疗组和标准疗法组,各131例。配对选取同期进行健康体检的131名儿童作为健康对照组。比较三组儿童的血清维生素D水平;比较维生素D治疗组的免疫指标水平;比较两组哮喘患儿的临床恢复指标。结果维生素D治疗组和标准疗法组各年龄段患儿血清25-羟基维生素D水平均低于正常值(20 ng/mL),且均显著低于健康对照组(P<0.05)。治疗后,维生素D治疗组各年龄段患儿血清25-羟基维生素D水平均显著高于治疗前及标准疗法组(P<0.05)。治疗后,三组IgE水平和EOS计数略低于治疗前,IgG和IgA水平略高于治疗前,但差异均不显著(P>0.05)。维生素D治疗组患儿肺部体征消失时间、临床症状缓解时间均显著短于标准疗法组,治疗后6个月以内平均发作次数均显著少于标准疗法组(P<0.05)。结论哮喘患儿的维生素D水平显著低于健康儿童,维生素D治疗辅助常规疗法可有效改善患儿的血清25-羟基维生素D水平,但对于免疫指标水平的改善作用不大。更多还原

【Abstract】 Objective To analyze the adjuvant treatment effect of vitamin D on asthmatic children aged 3 to 7 years.Methods A total of 262 children with asthma were selected as the research objects, all children were randomly divided into vitamin D treatment group and standard treatment group after stratified by age, sex and disease status, with 131 cases in each group. A total of 131 children who underwent physical examination at the same period were selected as healthy control group. The serum vitamin D level in the three groups were compared; the levels of immune indexes in vitamin D treatmnet group were compared; the clinical recovery indexs of asthma children in the two groups were compared. Results The level of serum 25-hydroxyvitamin D in the vitamin D treatment group and the standard treatment group in all age groups were lower than the normal value(20 ng/mL), and significantly lower than that in the healthy control group(P<0.05).After treatment, the level of serum 25-hydroxyvitamin D in the vitamin D treatment group in all age groups were significantly higher than those before treatment and in the standard treatment group(P<0.05). After treatment, IgE level and EOS count were slightly lower than those before treatment, and IgG and IgA levels were slightly higher than those before treatment, but the differences were not significant(P>0.05). The disappearance time of pulmonary signs and the remission time of clinical symptoms in the vitamin D treatment group were significantly shorter than those in the standard treatment group, and the average number of attacks within 6 months after treatment was significantly shorter than that in the standard treatment group(P<0.05). Conclusion The level of vitamin D in children with asthma are significantly lower than that in healthy children. Vitamin D therapy combined with conventional therapy can effectively improve the level of serum 25 hydroxyvitamin D in children, but it has little effect on the improvement of immune indexes.更多还原