【摘要】 目的探讨磁示踪技术用于触诊阴性乳腺结节标记定位的可行性。方法以1只雌性实验猪为动物模型,利用同轴双通道注射装置在乳腺组织内注射自行配制的海藻酸钠四氧化三铁溶液和钙剂,使其反应形成磁性水凝胶作为示踪磁体,在寻踪磁体配合下完成对标记的乳腺组织的切除。分别于注射后即刻、0.5 h和8 h获取乳腺组织肉眼观察磁性水凝胶形成情况;病理学观察磁性水凝胶及周旁乳腺组织有无磁性水凝胶弥散。结果海藻酸钠四氧化三铁溶液及钙剂注射顺利,注射后在注射部位可触及标记结节,并且寻踪磁体可吸起磁性水凝胶,能够完成精准定位。0.5 h和8 h获取注射部位磁性水凝胶及乳腺组织可见海藻酸钠四氧化三铁和钙剂凝胶化反应良好,肉眼和镜下均未见四氧化三铁微粒向周围组织弥散。结论利用海藻酸钠四氧化三铁溶液形成的磁性水凝胶可用于触诊阴性的乳腺结节的标记定位。更多还原

【Abstract】 Objective To explore the feasibility of magnetic tracer technique for palpation of negative breast nodules. Methods Using a female experimental pig as an animal model, a coaxial dual-channel injection device was used to inject the self-prepared sodium alginate ferric oxide solution and calcium agent into the breast tissue to make it react to form a magnetic hydrogel as a tracer magnet. The labeled breast tissue was excised with a pursuit magnet. The formation of magnetic hydrogel was observed with the naked eye of breast tissue immediately, 0.5 h and 8 h after injection, and the diffusion of magnetic hydrogel and peripheral breast tissue was observed pathologically. Results Sodium alginate ferric oxide solution and calcium were injected smoothly. After injection, the labeled nodules could be touched at the injection site, and the pursuit magnet could absorb magnetic hydrogel, which could complete accurate positioning. At 0.5 h and 8 h, the magnetic hydrogel and breast tissue of the injection site showed that the gelation reaction of sodium alginate ferric oxide and calcium agent was good, and no ferric oxide particles were dispersed to the surrounding by naked eye and under microscope. Conclusion Magnetic hydrogel formed by sodium alginate ferric oxide solution can be used to mark and locate breast nodules with negative palpation.更多还原