【摘要】 目的:分析无创正压通气联合呼吸兴奋剂治疗慢性阻塞性肺疾病（COPD）合并肺性脑病的临床效果。方法:选取2017年1月-2020年1月笔者所在医院收治的70例COPD合并肺性脑病患者,将其随机分为对照组和试验组,每组35例。所有患者均接受无创正压通气治疗,试验组在此基础上给予呼吸兴奋剂治疗。比较两组治疗效果。结果:治疗后,两组pH值比较差异无统计学意义（P>0.05）;治疗后,试验组PaO₂显著高于对照组,PaCO₂显著低于对照组,差异均有统计学意义（P<0.05）;治疗后,试验组IL-6、IL-8及IL-10均显著低于对照组,差异有统计学意义（P<0.05）。试验组通气时间（6.19±1.22）d、住院时间（11.29±1.39）d,均显著优于对照组的（8.29±1.23）、（15.77±1.55）d,差异有统计学意义（P<0.05）。结论:对COPD合并肺性脑病患者应用无创正压通气联合呼吸兴奋剂的治疗效果显著。更多还原

【Abstract】 Objective:To analyze the clinical effect of non-invasive positive pressure ventilation combined with respiratory stimulant in the treatment of chronic obstructive pulmonary disease （COPD） complicated with pulmonary encephalopathy.Method:A total of 70 patients with COPD complicated with pulmonary encephalopathy admitted in our hospital from January 2017 to January 2020 were selected and randomly divided into the control group and the experimental group,with 35 patients in each group.All patients received non-invasive positive pressure ventilation,and the experimental group was given respiratory stimulant on the basis of this.The therapeutic effects of the two groups were compared.Result:After treatment,there was no significant difference in pH value between the two groups （P>0.05）.After treatment,PaO₂ in the experimental group was significantly higher than that in control group,while PaCO₂ in the experimental group was significantly lower than that in control group,the differences were statistically significant （P<0.05）.After treatment,IL-6,IL-8 and IL-10 in the experimental group were significantly lower than those in control group,the differences were statistically significant （P<0.05）.The time of ventilation and hospitalization in the experimental group were （6.19±1.22） d and （11.29±1.39） d,which were significantly better than （8.29±1.23） d and （15.77±1.55） d in the control group,the differences were statistically significant （P<0.05）.Conclusion:Non-invasive positive pressure ventilation combined with respiratory stimulants has a significant effect on COPD patients complicated with pulmonary encephalopathy.更多还原