【摘要】 目的观察Santulli肠造瘘术治疗全结肠神经发育异常患儿的疗效。方法全结肠神经发育异常患儿30例分别行回肠末端Santulli肠造瘘术（A组,15例）和回肠末端单腔造瘘术（B组,15例）。比较两组手术时间、术中出血量等指标,术后第1、2、3个月复查血Na⁺和血HCO₃^-水平,随访再次手术情况。结果两组患儿均手术成功痊愈出院,无一例术后发生并发症。A组手术时间长于B组[（98.67±5.81） min vs.（92.00±3.68） min]（P<0.05）。术后第3个月,A组血Na⁺水平高于B组（P<0.05）。术后第2、3个月,A组血HCO₃^-水平高于B组（P<0.05）。25例再次手术的患儿均获得随访。7例行全结肠巨结肠根治术,术后无吻合口瘘发生;18例行关瘘术,3例出现术后并发症。结论 Santulli肠造瘘术治疗全结肠神经发育异常患儿是一种可行的手术方式。更多还原

【Abstract】 Objective To observe the efficacy of Santulli enterostomy in the treatment of the children with intestinal neuronal malformations of total colon.Methods Thirty children with intestinal neuronal malformations of total colon underwent Santulli enterostomy at the end of the ileum（group A,15 cases） or single-lumen enterostomy at the end of the ileum（group B,15 cases）.The operative time, intraoperative blood loss and other indicators were compared between the two groups.The blood Na⁺ and HCO₃^- levels were detected in the 1^st,2^nd and 3^rd month after operation and the reoperations were followed up.Results Both groups were successfully operated and discharged without postoperative complications.The operation time of group A was longer than that of group B [（98.67±5.81） minutes vs.（92.00±3.68） minutes]（P<0.05）.In the 3^rd month after operation, the blood Na⁺ level of group A was higher than that of group B（P<0.05）.The blood HCO₃^- level of group A was higher than that of group B in the 2^nd and 3^rd month after operation（P<0.05）.All the 25 children underwent reoperation were followed up, in whom 7 cases received total colon megacolectomy without anastomotic fistula, 18 cases received fistula closure（3 cases had postoperative complications）.Conclusion Santulli enterostomy is a feasible surgical procedure for the children with intestinal neuronal malformations of total colon.更多还原