【摘要】 目的:分析孤立性良恶性肺结节临床及CT特征,提高诊断的准确性。方法:回顾性分析南通大学附属丰县医院2017年1月至2020年12月经手术病理证实的100例孤立性肺结节患者临床及CT资料,通过单因素及多因素Logistic回归分析筛选出可能的危险因素。结果:100例孤立性肺结节患者中,良性25例,恶性75例。单因素分析显示两组在性别、年龄、吸烟史、COPD病史、家族肿瘤史、肿瘤标记物等一般资料间无统计学差异(P>0.05)。两组在结节最大长径、结节位置、瘤-肺界面、内部钙化、磨玻璃影(GGO)、分叶征、短毛刺征、胸膜凹陷征及血管集束征方面的差异均具有统计学意义(P<0.05)。多因素Logistic回归分析显示结节大小及GGO为孤立性良恶性肺结节的独立危险因素(P<0.05)。结论:对孤立性良恶性肺结节应重点观察结节最大长径、结节位置、瘤-肺界面、内部钙化、磨玻璃影(GGO)、分叶征、短毛刺征、胸膜凹陷征、血管集束征等征象,其中结节大小、GGO为恶性肺结节的独立危险因素。更多还原

【Abstract】 Objective: To analyze the clinical and CT features of solitary benign and malignant pulmonary nodule, and to improve the accuracy of diagnosis. Methods: The clinical and CT data of 100 patients with solitary pulmonary nodule confirmed by surgery and pathology in Fengxian Hospital Affiliated to Nantong University from January 2017 to December 2020 were retrospectively analyzed,and possible risk factors were screened out through single factor and multivariate Logistic regression analysis. Results: Among 100 patients with solitary pulmonary nodule, 25 cases were benign and 75 cases were malignant. Univariate analysis showed that there was no statistical difference between the two groups in general information such as gender, age, smoking history, COPD history, family tumor history, tumor markers(P>0.05), etc.There were statistically significant differences in the maximum length of nodule, nodule location, neoplasm-lung interface,internal calcification, ground glass shadow(GGO),lobulation sign, shorter spicule sign, pleural depression sign and vascular cluster sign between the benign and malignant pulmonary nodule(P<0.05). Multivariate logistic regression analysis showed that nodule size and GGO were independent risk factors for solitary benign and malignant pulmonary nodule(P<0.05). Conclusion: For the diagnosis of solitary benign and malignant pulmonary nodule,we should pay attention to maximum length of nodule, nodule location,neoplasm-lung interface, internal calcification,GGO, lobulation sign, burr sign, pleural depression sign and vascular cluster sign. Nodule size and GGO are independent predictors factors of malignance in patients with solitary pulmonary nodule.更多还原