【摘要】 目的探究卵巢畸胎瘤患者中发生抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的比例,并将合并抗NMDAR脑炎的卵巢畸胎瘤患者与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的临床特征进行总结对比。方法收集卵巢畸胎瘤患者的临床资料,将其分为合并抗NMDAR脑炎组与未合并抗NMDAR脑炎组,对其临床特征进行对比分析。结果共收集到168例卵巢畸胎瘤患者,其中14例(8.3%)合并抗NMDAR脑炎;合并抗NMDAR脑炎的卵巢畸胎瘤患者年龄低于未合并抗NMDAR脑炎的卵巢畸胎瘤患者[(23.8±5.5)岁vs.(29.8±9.1)岁,P=0.016]。合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以癌抗原125及血清铁蛋白升高为主,而未合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以糖类抗原199升高为主。合并抗NMDAR脑炎与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的肿瘤组织均可含有神经组织。结论卵巢畸胎瘤患者中发生抗NDMAR脑炎的比例不低,对于无明显症状的卵巢畸胎瘤患者,可考虑积极行手术治疗,以降低发生抗NMDAR脑炎的风险。更多还原

【Abstract】 Objective To determine the incidence of anti-N-methyl-D-aspartate receptor(NMDAR) encephalitis in patients with ovarian teratoma and to compare the clinical characteristics between ovarian teratoma patients with and without anti-NMDAR encephalitis. Methods Clinical data of ovarian teratoma patients were collected and divided into the anti-NMDAR encephalitis group and non-anti-NMDAR encephalitis group. Clinical characteristics were statistically compared between two groups. Results Among 168 patients with ovarian teratoma, 14 cases(8.3%) were complicated with anti-NMDAR encephalitis. The average age of ovarian teratoma patients complicated with anti-NMDAR encephalitis was significantly younger than that of their counterparts without anti-NMDAR encephalitis((23.8±5.5) years old vs.(29.8±9.1) years old, P =0.016). Cancer antigen 125(CA125) and serum ferritin levels were above the normal range in most ovarian teratoma patients complicated with anti-NMDAR encephalitis, and carbohydrate antigen 199(CA199) level was elevated in those without anti-NMDAR encephalitis. Pathological results revealed that nervous tissues could be detected in the tumor tissues in two groups. Conclusions The proportion of anti-NDMAR encephalitis in ovarian teratoma patients is relatively high. For ovarian teratoma patients without significant symptoms, surgery can be actively considered to reduce the risk of anti-NMDAR encephalitis.更多还原