【摘要】 先天性心脏病是导致儿童死亡的一个重要病因,为研究先天性心脏病的病理生理机制,建立稳定可靠的动物模型相当重要,建立体-肺动脉分流是模拟左向右分流型先天性心脏病的关键技术。现从外科建立分流技术的发展出发,介绍体-肺动脉分流对于建立动物模型的意义,以及以介入方式建立此分流的发展和在不同模型中的应用。更多还原

【Abstract】 Congenital heart disease is an important cause of death in children. To study the pathophysiological mechanisms of congenital heart disease,it is very important to establish a stable and reliable animal model. Systemic pulmonary arterial shunt is the key technology to simulate left-to-right shunt congenital heart disease. Based on the development of technology in surgically creating a shunt,this article introduces the significance of systemic pulmonary artery shunts for the establishment of animal model,as well as the development of intervention methods to establish this shunt and its application in different models.更多还原