【摘要】 目的探讨全身动脉粥样硬化斑块与脑梗死的关系。方法本研究纳入411例患者[(66.3±13.5)岁,男性52.9%],均进行全身血管超声检查。使用逻辑回归评估全身动脉粥样硬化斑块累及血管床数目、斑块部位与脑梗死的关系。结果脑梗死组的3～5个部位斑块检出率和颈动脉合并其他部位斑块检出率高于无脑梗死组,伴随白介素-6和心-踝血管指数的明显升高。在未调整的模型中,3～5个部位粥样硬化斑块组、颈动脉合并其他部位粥样硬化斑块组发生脑梗死风险分别是无斑块组的2.595倍(95%CI 1.338～5.031,P<0.01)和2.551倍(95%CI 1.317～4.942,P<0.01)。调整了性别和年龄后,斑块累及血管床数目和斑块部位与脑梗死的关系不显著。结论在未调整的模型中,与无斑块组相比,3～5个部位血管床粥样硬化斑块组和颈动脉合并其他部位粥样硬化斑块组发生脑梗死的风险更高。更多还原

【Abstract】 Objective We aimed to clarify the relationship between systemic atherosclerotic plaques and cerebral infarction.Methods The study included a total of 411 patients [( 66. 3 ± 13. 5) years of age,52. 9% of men]into the study. All the subjects underwent a systemic vascular ultrasound examination. The relationship between the number of vascular beds affected,the plaque site and cerebral infarction was assessed using logical regression.Results The detection rate of plaques in 3～5 sites and plaques in the carotid artery with other arteries were higher in the cerebral infarction group than that in non-cerebral infarction group,with a significant increase in the level of interleukin-6 and cardio-ankle vascular index.In the unadjusted model,the risk of stroke was 2. 595 times( 95%CI 1. 338～5. 031,P<0. 01) and 2. 551 times( 95%CI 1. 317～4. 942,P<0. 01) higher in the atherosclerotic plaque group at 3～5 sites and in the carotid artery with other atherosclerotic plaque sites than that in the non-atherosclerotic plaque group. After Adjusted for sex and age,this relationship was not significant. Conclusion In unadjusted models,the risk of cerebral infarction was higher in atherosclerotic plaque group of 3～5 sites and carotid artery with other arteries than that in non-atherosclerotic plaque group.更多还原