【摘要】 近年来,互联网与物联网等技术的快速发展为探寻精准医学与人工智能之间的关联应用提供了战略机遇。然而,如何组织、集成和共享复杂异构的生物医学数据业已成为阻碍该领域发展的严重技术挑战。本体因其能够提供知识与元数据层面的语义基础而推动了生物医学人工智能的发展,而基于互操作性的本体对异构知识与数据的整合和分析发挥着关键性的作用。将人工智能与精准医疗的有机集合称之为智能精准医疗,并提出一个"河马假设",用以阐明互操作性本体与智能精准医疗之间的正相关关系及如何发挥协同增效作用;同时,提出和展示了使用可扩展本体开发的原理和工具来实现本体的互操作性,进而支持智能精准医疗的应用与发展。此外,还对国内外互操作性本体的研究现状、本体中国的成立与发展以及医学伦理在智能精准医疗中的重要性等进行了综述和深入探讨。更多还原

【Abstract】 In recent years, the rapid development of technologies such as the Internet and the Internet of Things has provided strategic opportunities for exploring the related applications between precision medicine and Artificial Intelligence(AI).However, there has been a huge technical challenge in organizing, integrating, and sharing complex and heterogeneous biomedical big data.Ontologies promote the development of biomedical AI because they can provide semantic basis at the level of knowledge and metadata.Ontologies based on interoperability play a key role in the integration and analysis of heterogeneous knowledge and data.The combination of AI and precise medicine can be called Intelligent Precision Medicine(IPM).A Hippo Hypothesis is proposed to clarify the positive correlation between the establishment of interoperable ontologies and the achiverment of IPM and how to play.Meanwhile, the principles and tools of extensible ontology development is proposed to realize the interoperability of ontology, thus supporting the development of IPM.At the same time, some examples of interoperable ontologies and their applications in IPM are presented.In addition, the research status of interoperability ontology at home and abroad, the establishment and development of OntoChina, and the importance of medical ethics are also reviewed and discussed.更多还原