【摘要】 目的通过meta分析系统评价精神分裂症患者前瞻性记忆(PM)损伤特征。方法检索时间均从建库至2019年8月28日,检索PubMed、Embase、中国知网等数据库关于精神分裂症患者前瞻性记忆的随机对照试验研究,提取数据后,以纽卡斯尔-渥太华量表(NOS)进行文献质量方法评估。采用RevMan5.2软件对纳入文献的数据进行汇总分析。结果本研究包含19项病例对照研究(n=1 553),比较精神分裂症患者(n=823)和健康对照组(n=730)的前瞻性记忆损伤情况。meta分析结果显示,精神分裂症患者在基于时间的前瞻性记忆(TBPM),[SMD:-1.12(95%CI:-1.30,-0.95),P<0.001;I~2=60%];基于事件的前瞻性记忆(EBPM),[SMD:-1.07(95%CI:-1.25,-0.89),P<0.001;I~2=65%]和总体PM [SMD:-1.64(95%CI:-2.11,-1.18),P<0.001;I~2=87%]标准均数差与健康对照组相比差异有统计学意义。与健康对照组相比,基于活动的前瞻性记忆(ABPM)未达到显著[SMD:-0.52(95%CI:-1.07,0.03),P<0.06;I~2=74%]。结论精神分裂症患者存在前瞻性记忆的损伤,以TBPM和EBPM更为突出,而ABPM损害较轻。更多还原

【Abstract】 Objective To systematically evaluate the characteristics of prospective memory(PM) impairment in patients with schizophrenia through meta-analysis. Methods The search time was from the establishment of the database to August 28, 2019. The randomized controlled trial studies on prospective memory of patients with schizophrenia were searched in PubMed, Embase, CNKI and other databases. After the data were extracted, the Newcastle-Ottawa scale(NOS) conduct a methodological assessment of literature quality. RevMan 5.2 software was used to summarize and analyze the data included in the literature. Results This study included 19 case-control studies(n=1 553), comparing the prospective memory impairment of patients with schizophrenia(n=823) and healthy controls(n=730). The results of the meta-analysis showed that patients with schizophrenia had timebased prospective memory(TBPM), [ SMD:-1.12(95% CI:-1.30,-0.95), P<0.001; I~2=60% ]; event-based Prospective memory(EBPM), [ SMD:-1.07(95%CI:-1.25,-0.89), P<0.001; I~2=65% ] and overall PM [ SMD:-1.64(95%CI:-2.11,-1.18), P<0.001; I~2=87%] the difference between the standard mean difference and the healthy control group is statistically significant. Compared with the healthy control group, activity-based prospective memory(ABPM) did not reach significant [SMD:-0.52(95% CI:-1.07, 0.03), P<0.06; I~2=74%]. Conclusion Patients with schizophrenia have prospective memory impairment, TBPM and EBPM are more prominent, while ABPM damage is less.更多还原