【摘要】 目的探究重组人促卵泡激素联合地屈孕酮对多囊卵巢综合征不孕患者卵巢功能的影响。方法选取2019年5月至2020年5月恩施土家族苗族自治州中心医院收治的106例多囊卵巢综合征患者作为研究对象,按照随机分组法分为地屈孕酮组（n=53）与联合治疗组（n=53）。地屈孕酮组采用地屈孕酮治疗,联合治疗组采用重组人促卵泡激素联合地屈孕酮治疗。对两组性激素、卵巢血流动力学指标,瘦素（LEP）、内脂素（VF）水平,腰臀比,卵巢体积、卵泡个数,治疗有效率及不良反应进行比较。结果治疗后,与地屈孕酮组比较,联合治疗组雌二醇（E₂）、收缩期峰值流速（PSV）、搏动指数（PI）水平较高,黄体生成素（LH）、卵泡刺激素（FSH）、阻力指数（RI）、LEP、VF、腰臀比均较低（P<0.05）。与地屈孕酮组比较,联合治疗组治疗有效率较高（P<0.05）。结论地屈孕酮联合重组人促卵泡激素对多囊卵巢综合征不孕患者进行治疗,能够改善卵巢功能障碍,促进排卵,抑制糖脂代谢紊乱,改善卵泡发育障碍,具有一定临床应用价值。更多还原

【Abstract】 Objective To investigate the effects of recombinant human follicle stimulating hormone combined with dydrogesterone on ovarian function in infertile patients with polycystic ovary syndrome. Methods A total of 106 patients with polycystic ovary syndrome（PCOS） admitted to the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from May 2019 to May 2020 were selected and randomly divided into the didrogesterone group（n=53） and the combined treatment group（n=53）. The dydrogesterone group was treated with dydrogesterone, and the combined treatment group was treated with recombinant human follicle-stimulating hormone combined with dydrogesterone. Sex hormone, ovarian hemodynamic indexes, leptin（LEP）, endoliptin（VF） levels, waist-to-hip ratio, ovarian volume, number of follicles, treatment efficiency and adverse reactions were compared between the two groups. Results After treatment, compared with the dydrogesterone group, the levels of estradiol（E₂）, peak systolic velocity（PSV） and pulse index（PI） were higher in the combined treatment group, while the levels of luteinizing hormone（LH）, follicle stimulating hormone（FSH）, resistance index（RI）, LEP, VF and waist-to-hip ratio were lower in the combined treatment group（P<0.05）. Compared with the dydrogesterone group, the combined treatment group had a higher effective rate（P<0.05）. Conclusions Dextrogesterone combined with recombinant human follicle-stimulating hormone can improve ovarian dysfunction, promote ovulation, inhibit glucose and lipid metabolism disorders, and improve follicular development disorder in the treatment of infertility patients with polycystic ovary syndrome, which has certain clinical application value.更多还原