【摘要】 目的研究乌拉地尔联合酚妥拉明对妊娠高血压的治疗效果及对高迁移率族蛋白1(HMGB1)、脂联素(APN)水平的影响。方法选取2016年6月至2017年6月湖北省宜昌市第三人民医院诊治的92例妊娠高血压患者作为研究对象。随机分为联合组(n=46)和酚妥拉明组(n=46)。酚妥拉明组给予酚妥拉明注射液治疗,联合组在酚妥拉明组基础上给予乌拉地尔治疗。检测两组HMGB1、APN、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血压水平,统计两组不良结局发生率、不良反应发生率。结果治疗后,两组HMGB1、TNF-α、IL-6水平以及舒张压、收缩压、平均动脉压均低于治疗前,APN水平高于治疗前,差异具有统计学意义(P<0.05);治疗后,联合组HMGB1、TNF-α、IL-6水平以及舒张压、收缩压、平均动脉压低于酚妥拉明组,APN水平高于酚妥拉明组,差异具有统计学意义(P<0.05);联合组不良结局发生率低于酚妥拉明组,差异具有统计学意义(P<0.05);联合组不良反应发生率高于酚妥拉明组,差异无统计学意义(P>0.05)。结论乌拉地尔联合酚妥拉明对妊娠高血压的治疗效果显著,能改善患者HMGB1和APN水平以及母婴结局,控制患者血压。更多还原

【Abstract】 Objective To investigate the effect of urapidil combined with phentolamine on pregnancy induced hypertension and the level of high mobility group protein 1(HMGB1) and adiponectin(APN). Methods A total of 92 pregnancy-induced hypertension patients treated in Yichang Third People′s Hospital from June 2016 to June 2017 were selected as the research subjects, and randomly divided into combined group(n=46) and phentolamine group(n=46). The phentolamine group was treated with phentolamine injection, and the combined group was combined with Urapidil on the basis of the phentolamine group.The levels of HMGB1, APN, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and blood pressure in the two groups were detected, and the incidence of adverse outcomes and adverse reactions in the two groups were statistically analyzed. Results After treatment, the levels of HMGB1, TNF-α, IL-6, diastolic blood pressure, systolic blood pressure and mean arterial blood pressure in 2 groups were lower than before treatment, and the level of APN was higher than before treatment(P<0.05). The levels of HMGB1, TNF-α, IL-6, diastolic blood pressure, systolic blood pressure and mean artery in combined group were lower than those in phentolamine group, while the level of APN in combined group was higher than that in phentolamine group(P<0.05).The incidence of adverse outcomes in the combined group was lower than that in the phenolamine group(P<0.05).The incidence of adverse reactions in the combined group was higher than that in the phentolamine group(P>0.05). Conclusions Urapidil combined with phentolamine has significant therapeutic effect on pregnancy hypertension, which can improve HMGB1 and APN levels, maternal and infant outcomes, and control blood pressure of patients.更多还原