【摘要】 目的探讨砂砾性假痛风(CPPD)临床病理特点,为进一步认识本病进行系统的回顾性分析。方法收集2013年1月至2019年12月西南医科大学附属医院病理科CPPD的组织标本及临床病理资料,采用免疫组化染色检测CD68及S-100的表达。结果免疫组化染色:组织细胞和多核巨细胞CD68(+),化生性软骨S-100(+)。CPPD影像学表现为纤维软骨及透明软骨钙化,偏振光显微镜下可见焦磷酸二氢钙结晶体。结论 CPPD是一种慢性代谢相关性疾病,临床常需与痛风、类风湿关节炎、骨性关节炎等具有相似症状的疾病相鉴别。更多还原

【Abstract】 Objective To investigate the clinicopathological features of CPPD and to provide a systematic review about the disease.Methods CPPD and histopathological data from the Department of pathology at the Affiliated Hospital of Southwest Medical University from January 2013 to December 2019 were collected,and the expression of CD68 and S-100 was detected by immunohistochemical staining. Results Immunohistochemical staining showed tissue cells and multinucleated giant cells CD68 were positive and metaplastic cartilage S-100 were positive too. CPPD showed calcification of fibrocartilage and hyaline cartilage,and calcium dihydrogen pyrophosphate crystal was seen under polarized light microscope. Conclusion CPPD is a chronic metabolic related disease. It is often needed to identify this diseases from gout, rheumatoid arthritis and osteoarthritis.更多还原