【摘要】 目的:探讨分析新型冠状病毒肺炎(COVID-19)成人患者合并肺炎支原体感染的临床特征。方法:回顾性分析2020年1月至3月,鄂州市中心医院收治的COVID-19患者,将入院后完成肺炎支原体血清学检测的患者纳入研究,分为合并支原体感染组(MP组)和未合并肺炎支原体感染组(MONO组),比较两组一般情况、发病时症状、实验室检查结果、胸部CT影像、主要治疗及预后情况。结果:共纳入了符合条件的356例患者,80例(22.5%)合并肺炎支原体感染,与MONO组相比,MP组平均年龄明显小于MONO组(47 vs. 55岁,P=0.003),且女性明显多于男性(65%vs. 35%,P=0.001),肌肉酸痛症状发生率高(OR=2.46, 95%CI:1.02～5.91,P=0.044),两组患者的基础疾病、胸部CT影像、临床分型和预后方面差异无统计学意义;对年龄≥65岁的老年患者亚组分析显示,与MONO组相比,MP组D-二聚体水平升高(P=0.04)、应用机械通气的比例增加(P=0.031)、住院时间明显延长(28 d vs. 21.5 d,P=0.045)。结论:COVID-19合并肺炎支原体感染不少见,年轻者、女性易合并感染,合并感染会延长老年患者的住院时间。更多还原

【Abstract】 Objective: To explore the clinical features of adult corona virus disease-19(COVID-19)patients complicated with concomitant infection of mycoplasma pneumoniae and to elucidate the impact of the co-infection on in-hospital prognosis. Methods: A retrospective study was conducted on all adult patients hospitalized for COVID-19 in Ezhou Central Hospital from January 17 to March 27 2020, for who the detection of serological antibody of M. pneumoniae was completed at the admission. Results: Out of all 356 subjects diagnosed with COVID-19, 80(22.5%) patients were verified to have co-infection of M. pneumoniae. Patients with versus those without the evidence of M. pneumoniae infection were younger, had higher proportion of female, and were more likely to present with the symptom of muscle soreness(OR=2.46, 95%CI:1.02-5.91, P=0.044). Despite no significant difference existed between groups as to laboratory findings, imaging features and mortality as well, patients with M. pneumoniae co-infection demonstrated higher level of serum D-dimer(2.31 vs. 1.52μg/mL, P=0.04), greater risk of mechanical ventilation, and prolonged hospital stay(28 d vs. 21.5 d, P=0.04) than those with mere COVID-19 infection. Conclusions: Co-infection of M. pneumoniae with COIVD-19 is prevalent in COIVD-19 patients, which warrants routine test for M. pneumoniae to identify individuals in need of further assessment and intervention.更多还原