【摘要】 目的探讨臭氧自血疗法（O₃-AHT）对慢性心力衰竭（CHF）患者心功能及炎症因子的影响。方法选择2018年5月至2019年6月在浙江大学医学院附属金华医院住院的CHF患者64例,分为O₃-AHT组和对照组。比较两组治疗前后脑钠肽（BNP）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）水平及明尼苏达心力衰竭生活质量量表（MLHFQ）评分,同时比较治疗后6个月与治疗前心脏结构和功能指标。结果治疗后O₃-AHT组BNP、CRP、IL-6、TNF-α水平及MLHFQ评分[（647.76±238.03）pg/m L、（3.54±1.98）mg/L、（5.53±3.02）pg/m L、（1.73±1.28）pg/m L、（32.39±5.81）分]均低于对照组（均P<0.05）。两组治疗后上述指标均较治疗前降低（均P<0.01）。治疗后两组的左心室舒张末期内径（LVEDd）和左心室收缩末期内径（LVESd）缩小,左心室射血分数（LVEF）较治疗前增加,O₃-AHT组LVEDd、LVESd及LVEF[（50.35±8.32）mm、（36.23±6.94）mm、（42.94±6.71）%]均大于对照组（均P<0.05）。结论 O₃-AHT辅助治疗有助于控制CHF患者的炎症反应并改善心脏结构和功能。更多还原

【Abstract】 Objective To investigate the effect of ozone autohemotherapy（O₃-AHT） on cardiac function and inflammatory factors in patients with chronic heart failure（CHF）. Methods 64 inpatients with CHF were randomly divided into O₃-AHT group and control group. The levels of B-type natriuretic peptide（BNP）, C-reactive protein（CRP）, tumor necrosis factor-α（TNF-α）, interleukin-6（IL-6） and Minnesota Heart Failure Quality of life scale（MLHFQ） score before and after the treatment were compared between the two groups. Cardiac structure and function were compared before and 6-month later after the treatment. Results BNP, CRP, IL-6, TNF-α and MLHFQ score [（647.76±238.03） pg/m L、（3.54±1.98） mg/L、（5.53±3.02） pg/m L、（1.73±1.28） pg/m L、（32.39±5.81） points]were significantly lower in O₃-AHT group than in control group after treatment（all P<0.05）. They were significantly lower after than before treatment in both groups（all P <0.01）. Left ventricular（LV） end diastolic dimension and LV end systolic dimension decreased and LV ejection fraction increased in both groups after treatment. These changes were more significantly in O₃-AHT group [（50.35±8.32）mm、（36.23±6.94） mm、（42.94±6.71）%] than in control group（all P<0.05）. Conclusion O₃-AHT adjuvant therapy may reduce inflammation response and improve cardiac structure and function in CHF patients.更多还原