【摘要】 背景:大量研究认为,运动可以起到改善阿尔茨海默症小鼠病程的作用,但是也有部分研究持不同观点,而运动是否与改善阿尔茨海默症小鼠病程之间存在一定的剂量关系,目前还没有明确的结论。目的:评估运动与改善阿尔茨海默症小鼠病程之间的剂量效应,并得出较为明确的运动剂量阈值。方法:以英文检索词"exercise,running,Alzheimer’s disease,AD,mice"及中文检索词"运动,阿尔茨海默,小鼠,老年痴呆"分别检索Web of Science(核心合集)、PubMed、CNKI等数据库,获取相关研究文献,并对其进行研究,然后按照一定逻辑进行分析和综述。结果与结论:运动与改善阿尔茨海默症小鼠病程之间存在一定的剂量效应。自主转轮运动的运动剂量可能为平均速度大于2.5 m/min,频率为7 d/周,持续时间每天不低于12 h,总持续时间不低于3周时,阿尔茨海默症小鼠的病程才有可能得到改善;跑台运动的运动剂量可能为速度大于10 m/min,频率不低于5 d/周,持续时间不低于9周时,阿尔茨海默症小鼠的病程才有可能得到改善。但是,想要更好地确定运动的剂量效应及其阈值,仍然还有很多的工作要做。更多还原

【Abstract】 BACKGROUND: A large number of studies believe that exercise can ameliorate the disease course of Alzheimer’s disease mice, but some studies hold different views. It is unclear whether there is a certain dose relationship between exercise and the improvement of the disease course in Alzheimer’s disease mice.OBJECTIVE: To evaluate the dose-effect relationship between exercise and improvement of the disease course in Alzheimer’s disease mice, and to obtain a relatively definite exercise dose threshold.METHODS: Web of Science Core Collection, PubMed, and CNKI were searched for relevant literature using the keywords of "exercise; running; Alzheimer’s diseases; AD; mice" in English and Chinese, respectively. Then the included literature were logically analyzed and reviewed. RESULTS AND CONCLUSION: There was a certain dose-effect relationship between exercise and improvement of disease course in Alzheimer’s disease mice. The disease course of Alzheimer’s disease mice could be improved only when the average speed of voluntary wheel running was greater than 2.5 m/min, no less than 12 hours a day, 7 days per week, for no less than 3 continuous weeks in total as well as when the speed of treadmill running was more than 10 m/min, no less than 5 days per week, for no less than 9 weeks. However, there is still a lot of work to be done to better determine the dose effect of exercise and its threshold.更多还原