【摘要】 背景:有研究表明股骨头坏死是骨科难治愈的疾病,探索股骨头坏死领域的研究现状和研究热点有利于把握研究方向,促进股骨头坏死领域的发展,使之更好地服务于临床。目的:探究股骨头坏死近5年来的发展现状和预测该领域未来的研究热点,为相关研究人员提供借鉴。方法:在Web of Science数据库的科学引文指数扩展数据库中以"股骨头坏死"为主题搜索2016至2020年有关于股骨头坏死的文献。VOSviewer软件进行关键词共现分析、作者合著分析、机构合著分析、国家合著分析及文献共被引分析。结果与结论:①根据关键词共现分析可将股骨头坏死目前的研究分为以下几类:股骨头坏死的危险因素、诊断和治疗、矫形术、细胞生物学、基因遗传学;②激素性股骨头坏死、骨髓间充质干细胞、成骨分化是近期的研究热点,但激素性股骨头坏死的发病机制和治疗方法尚未阐明以及间充质干细胞的作用机制和治疗效果尚不明确,所以推测在未来的一段时间里,有关两者围绕成骨分化过程的研究将会有很大的发展空间;③结果证实,对股骨头坏死机制的进一步挖掘及改善其治疗方法是未来的重要研究内容,激素性股骨头坏死机制的探讨和骨髓间充质干细胞用于股骨头坏死的治疗将会围绕成骨分化过程开展更深层次的研究。更多还原

【Abstract】 BACKGROUND: Studies have indicated that femoral head necrosis is a refractory disease in orthopedics. To explore the research status and research focus in the field of osteonecrosis of the femoral head is beneficial to grasp the research direction, promote the development of the field of femoral head necrosis, and make it better serve the clinical practice.OBJECTIVE: To explore the development of research hotspots on osteonecrosis of the femoral head in the past 5 years and predict the future research focus in this field, and to provide reference for relevant researchers.METHODS: Base on the Science Citation Index Extended database of the Web of Science database, we search for literature on osteonecrosis of the femoral head from 2016 to 2020 with the theme of "osteonecrosis of the femoral head," and the VOSviewer software was applied for visualization analysis, including keyword co-occurrence analysis, co-author analysis, institutional co-authoring analysis, country co-authoring analysis, and co-citation analysis. RESULTS AND CONCLUSION: Based on keyword co-occurrence analysis, current research on osteonecrosis of the femoral head is divided into four main categories: risk factors, diagnose and treatment, orthormorphia, cell biology, genetics heredity of osteonecrosis of the femoral head. Steriod-induced osteonecrosis of the femoral head, bone marrow mesenchymal stem cells, and osteogenic differentiation are recent research hotspots in the field of osteonecrosis of the femoral head. However, the pathogenesis and treatment methods of steroid-induced osteonecrosis of the femoral head have not yet been clarified, and the mechanism of action and therapeutic effects of mesenchymal stem cells are still unclear. Therefore, it is speculated that further excavation of the mechanism of femoral head necrosis and improvement of its treatment are important research contents in the future. To conclude, the mechanism of steroid-induced osteonecrosis of the femoral head and the therapy of bone marrow mesenchymal stem cells for osteonecrosis of the femoral head will be studied deeply around the process of osteogenic differentiation.更多还原