【摘要】 背景:既往研究发现胃肠疾病患者头痛的发生率较高，而偏头痛患者常伴有胃肠道症状。了解疾病之间的关联可为其机制的研究和治疗提供新思路。目的:探索胃食管反流病(GERD)、功能性消化不良(FD)和肠易激综合征(IBS)与无先兆偏头痛(MWoA)的共患情况以及相关危险因素。方法:采用随机分层抽样的方法对陕西省2 696名成年农村居民进行问卷调查，依据ICHD-Ⅲβ诊断标准、蒙特利尔标准、罗马Ⅳ标准分别诊断MWoA、GERD、FD和IBS,计算单病患病率以及与MWoA的重叠患病率，比较MWoA组与非MWoA组之间GERD、FD和IBS的患病率，并分析各个疾病的相关危险因素。结果:本研究共收集有效问卷2 423份，GERD、FD、IBS的患病率分别为12.5%、15.6%、6.9%,MWoA的患病率为8.8%。MWoA组GERD(30.5%对10.7%)、FD(37.1%对13.5%)、IBS(27.2%对4.9%)的患病率均高于非MWoA组(P均<0.001)。多因素分析显示，女性、高血压、运动系统慢性损伤疾病史均与GERD、FD、IBS以及MWoA的患病呈正相关。结论:GERD、FD和IBS与MWoA之间存在一定的关联。更多还原

【Abstract】 Background: Previous studies have found that patients with gastrointestinal diseases have a higher incidence of headache, while migraine patients are often accompanied by gastrointestinal symptoms. Understanding the relationship between diseases can provide new ideas for the study of its mechanism. Aims: To explore the co-occurrence and related risk factors of gastroesophageal reflux disease(GERD), functional dyspepsia(FD), irritable bowel syndrome(IBS) and migraine without aura(MWoA). Methods: A total of 2 696 adult rural residents in Shaanxi Province were investigated by random stratified sampling. MWoA, GERD, FD and IBS were diagnosed based on ICHD-Ⅲβ, Montreal classification and Rome Ⅳ, respectively. The prevalence of the single disease and overlapping prevalence of MWoA were calculated. The prevalence rates of GERD, FD and IBS between MWoA group and non-MWoA group were compared, and the disease-related risk factors were analyzed. Results: In this study, a total of 2 423 valid questionnaires were collected. The prevalence rates of GERD, FD and IBS were 12.5%, 15.6% and 6.9%, respectively, and the prevalence rate of MWoA was 8.8%. The prevalence rates of GERD(30.5% vs. 10.7%), FD(37.1% vs. 13.5%) and IBS(27.2% vs. 4.9%) in MWoA group were all higher than those in non-MWoA group(P all <0.001). Multivariate analysis showed that female, hypertension, chronic motor system diseases were positively correlated with GERD, FD, IBS and MWoA. Conclusions: There is a certain association between GERD, FD, IBS and MWoA.更多还原