【摘要】 幽门螺杆菌(Hp)感染与胃癌紧密相关,随着根除治疗的推行,Hp的感染率逐渐下降,由Hp感染所致胃癌的比例也随之下降。幽门螺杆菌阴性胃癌(HpNGC)有可能成为更常见的胃癌类型。近年发现幽门螺杆菌阳性胃癌(Hp PGC)与HpNGC的病理生物学行为存在差异,表明HpNGC的发病机制可能与Hp PGC并不相同。有研究发现HpNGC中microRNA(miRNA)的表达谱不同于Hp PGC,说明差异表达的miRNA在HpNGC的发病过程中发挥重要作用。本文就差异表达的miRNA在HpNGC致病机制和诊治中的研究进展作一综述,以期为探寻HpNGC的发病机制提供新的思路。更多还原

【Abstract】 Helicobacter pylori( Hp) infection is closely related to gastric cancer,and with the implementation of eradication therapy,the infection rate of Hp decreases gradually and the proportion of gastric cancer caused by Hp infection also decreases accordingly. Hence,Helicobacter pylori-negative gastric cancer( HpNGC) become a more common type of gastric cancer. It has been reported in recent years that there are some differences in pathobiological behavior between Helicobacter pylori-positive gastric cancer( Hp PGC) and HpNGC,which indicates that the pathogenesis of HpNGC may be different from that of Hp PGC. Relevant studies have found that the expression profile of microRNAs( miRNAs) in HpNGC is different from that in Hp PGC,suggesting that the differentially expressed miRNAs may play an important role in the pathogenesis of HpNGC. This article reviewed the research progress on miRNAs in the pathogenesis,diagnosis and treatment of HpNGC,providing a new insight for exploring the pathogenesis of HpNGC.更多还原