【摘要】 目前新型冠状病毒肺炎(COVID-19)在全球范围内引起大流行,其是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的急性呼吸道传染病,该病毒属于β冠状病毒属,与严重急性呼吸综合征(SARS)病毒具有79%的同源性。尽管COVID-19患者的典型症状为发热、咳嗽等呼吸道感染症状,但仍有部分患者会出现消化系统表现。研究表明SARS-CoV-2受体血管紧张素转换酶2(ACE2)在胃肠道、肝脏以及胰腺细胞中表达,且在COVID-19患者粪便中检出了SARS-CoV-2 RNA,提示粪-口途径是SARS-CoV-2潜在的传播途径。本文就COVID-19患者消化系统受累的临床表现及其发病机制作一综述。更多还原

【Abstract】 COVID-19 currently is a major pandemic disease in the world. It is caused by the severe acute respiratory syndrome coronavirus 2( SARS-CoV-2),a member of the β-coronavirus genus that has 79% homology with severe acute respiratory syndrome( SARS) virus and can lead to acute respiratory infection. While COVID-19 patients typically present with respiratory symptoms such as fever,cough,some patients also report symptoms of digestive system. Studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients,and the viral receptor angiotensin converting enzyme2( ACE2) is found to be expressed in gastrointestinal epithelial cells,hepatic cells and pancreatic cells,suggesting that fecal-mouth route is a potential route for transmission of SARS-CoV-2. This article reviewed the digestive manifestations and pathogenesis of patients with COVID-19.更多还原