【摘要】 目的探讨广泛性焦虑障碍量表-2(Generalized Anxiety Disorder-2,GAD-2)评估功能性消化不良(functional dyspepsia, FD)患者伴焦虑状态对疾病严重度、躯体化和生命质量的影响。方法收集符合罗马Ⅳ标准确诊的FD患者440例,完成GAD-7、GAD-2、消化不良症状严重度量表(DSS)、躯体化症状群量表(改编的PHQ-15)以及尼平消化不良指数简表(NDI),与GAD-7比较,分析GAD-2评估焦虑状态的发生率,并探讨其与DSS、躯体化、NDI的关系。采用t检验、χ~2检验、Spearman相关系数、多元线性回归分析进行统计分析。结果 GAD-2和GAD-7评估FD患者伴焦虑状态发生率分别为26.6%和17.3%(χ~2=11.157,P=0.001)。相关分析显示,GAD-2(r=0.178,P=0.000)和GAD-7(r=0.146,P=0.000)与DSS相关;GAD-2(r=0.342,P=0.000)和GAD-7(r=0.322,P=0.000)与躯体化(改编的PHQ-15)均相关;GAD-2(r=0.391,P=0.000)和GAD-7(r=0.406,P=0.000)与NDI均相关。多元线性回归分析显示,GAD-2量表评估的焦虑(β=0.184,P=0.000)、抑郁(β=0.238,P=0.000)、躯体化(β=0.537,P=0.000)是NDI的影响因素;GAD-7量表评估的焦虑(β=0.259,P=0.000)、抑郁(β=0.176,P=0.002)、躯体化(β=0.528,P=0.000)是NDI的影响因素。结论 GAD-2定性诊断FD患者伴焦虑状态可能更敏感,GAD-2评估焦虑状态对躯体化、DSS的影响可能较GAD-7更明显,这些结果提示临床上可用GAD-2快速评估FD患者伴焦虑状态。更多还原

【Abstract】 Objective To explore the effects of anxiety assessed by Generalized Anxiety Disorders-2(GAD-2) on disease severity, somatization and quality of life in patients with functional dyspepsia(FD).Methods 440 patients with FD diagnosed according to Rome Ⅳ standard were collected and completed GAD-2, GAD-7, Dyspepsia Symptom Severity(DSS), adapted Patient Healthy Questionnaire-15(adapted PHQ-15) and Nepean Dyspepsia Index-Short Form(NDI). Compared with GAD-7, the incidence of anxiety assessed by GAD-2 and its relationship with DSS, somatization and NDI was evaluated. Statistical analysis was carried out by t-test, χ~2 test, Spearman correlation coefficient and multiple linear regression analysis.Results The incidence of anxiety in patients with FD with GAD-2 and GAD-7 were 26.6% and 17.3%(χ~2=11.157, P=0.001), respectively. Correlation analysis showed that GAD-2(r=0.178, P=0.000) and GAD-7(r=0.146, P=0.000) were related to DSS, GAD-2(r=0.342, P=0.000) and GAD-7(r=0.322, P=0.000) were related to somatization(adapted PHQ-15), GAD-2(r=0.391, P=0.000) and GAD-7(r=0.406, P=0.000) were related to NDI. Multiple linear regression analysis showed that anxiety assessed by GAD-2(β=0.184, P=0.000), depression(β=0.238, P=0.000) and somatization(β=0.537, P=0.0000) were the influencing factors of NDI, and anxiety assessed by GAD-7(β=0.259, P=0.000), depression(β=0.176, P=0.002) and somatization(β=0.528, P=0.000) were the influencing factors of NDI. Conclusion The qualitative diagnosis of GAD-2 for FD patients with anxiety state may be more sensitive than that of GAD-7. Anxiety state evaluation with GAD-2 may have a greater impact on somatization and DSS than GAD-7 in FD patients. These results suggest that GAD-2 may be used to quickly evaluate the anxiety state of FD patients.更多还原