【摘要】 目的胰岛素、利福喷丁综合疗法联合胸腺肽α1对肺结核合并糖尿病效果观察。方法选取2018年10月—2020年8月期间该院收治的80例肺结核合并糖尿病患者为研究病例,以随机动态数表以及单组40例标准为依据,划分为对照组、试验组;对照组开展胰岛素、利福喷丁综合疗法,试验组基于对照组另行胸腺肽α1疗法;对比分析两组患者治疗后的T淋巴细胞计数、痰菌转阴率、空洞闭合率、病灶吸收率以及治疗前后的血糖值。结果经治疗试验组患者的CD4~+、CD4~+/CD8~+均高于对照组,CD8~+低于对照组,差异有统计学意义(P<0.05);试验组患者的痰菌转阴率、空洞闭合率、病灶吸收率优于对照组,差异有统计学意义(P<0.05);而治疗后试验组的空腹血糖、餐后2 h血糖均低于对照组,差异有统计学意义(P<0.05)。结论胰岛素、利福喷丁综合疗法联合胸腺肽α1治疗肺结核合并糖尿病,可改善患者的T淋巴细胞亚群与肺结核体征,同时还有利于更好地管控患者的血糖值,临床应用价值显著。更多还原

【Abstract】 Objective To observe the effect of combined therapy of insulin and rifapentin combined with thymosin α1 on tuberculosis complicated with diabetes. Methods From October 2018 to August 2020, 80 patients with tuberculosis and diabetes mellitus admitted to the hospital were selected as the study cases. Based on the random dynamic number table and the standard of 40 cases in a single group, they were divided into the control group and the experimental group; the control group was carried out insulin and rifapentin combined therapy, the experimental group was based on the control group with additional thymosin α1 therapy; comparative analysis of the T lymphocyte count, sputum conversion rate, cavity closure rate,lesion absorption rate and blood glucose before and after treatment in the two groups value. Results The CD4~+ and CD4~+/CD8~+ of the treated experimental group were higher than those of the control group, and the CD8~+ was lower than the control group, the difference was statistically significant(P<0.05); the negative rate of sputum bacteria in the experimental group,cavity closure rate, and the rate of lesion absorption was higher than that of the control group, and the difference was statistically significant(P <0.05); and the fasting blood glucose and 2 h postprandial blood glucose of the test group after treatment were lower than those of the control group,the difference was statistically significant(P <0.05).Conclusion The combined therapy of insulin and rifapentin combined with thymosin α1 in the treatment of pulmonary tuberculosis with diabetes can improve the patient’s T lymphocyte subsets and pulmonary tuberculosis signs. It is also conducive to better control of the patient’s blood glucose level. The clinical application value is significant.更多还原