【摘要】 目的了解并分析孤独症谱系障碍(autism spectrum disorder,ASD)的临床相关发病因素,探究25-羟维生素D在ASD儿童中的水平变化,为ASD的防治提供理论依据。方法采用1:2配对病例对照研究,观察组为2017年2月～2019年2月于潍坊市妇幼保健院儿童康复科确诊ASD儿童103例,对照组为同一机构年龄、性别匹配的体检发育正常儿童206例。对ASD常见发病影响因素进行单因素分析,将有统计学差异的所有因素进入非条件多因素Logisitic回归模型进行分析,筛选出ASD的主要影响因素。结果 ASD儿童独立的危险因素有经常接触电子产品、母孕期精神紧张及心理压力大、母孕期饮食习惯不当、母孕期工作或居住地靠近公路或工厂、母亲为高龄产妇;ASD儿童血清25-羟维生素D平均水平为19.87±4.94 ng/ml,对照组儿童血清25-羟维生素D平均水平为24.90±4.84 ng/ml,ASD组25-羟维生素D水平显著低于对照组(P<0.05)。结论 (1)提倡正确的育儿方式,母孕期健康的社会心理、健康饮食、良好的居住及工作环境、适龄生育,从而达到降低ASD发生风险的目标。(2)维生素D缺乏或不足可能是影响孤独症谱系障碍的因素之一。更多还原

【Abstract】 Objective To understand and analyze the influencing factors of autism spectrum disorder(ASD),and to explore the changes of 25-hydroxyvitamin D level in children with ASD, so as to provide theoretical basis for the prevention and treatment of ASD. Methods 1:2 matched case-control study was used. The observation group consisted of 103 children with ASD diagnosed in the Child Rehabilitation Department of Weifang Maternity and Child Health Hospital from February 2017 to February 2019. The control group included 206 children with normal development who came from the same medical institution’s age-and gendermatched physical examination. A single factor analysis was performed on the common influencing factors of ASD, and all the factors with statistical differences were entered into the unconditional multi-factor Logisitic regression model for analysis, and the main influencing factors of ASD were screened out. Results(1) Independent risk factors for ASD children were: frequent exposure to electronic products, maternal stress and high psychological stress during pregnancy, improper eating habits during pregnancy, working or living place during pregnancy near the road or factory, the mother is an elderly mother.(2) The average serum 25-hydroxyvitamin D level of children with ASD was 19.87±4.94 ng/ml, while the average serum 25-hydroxyvitamin D level of children in the control group was 24.90±4.84 ng/ml. The level of 25-(OH)D in the ASD group was lower than that in the control group with statistically significant difference(P<0.05). Conclusions(1) Promoting correct parenting methods, healthy social psychology during pregnancy, healthy diet, a good living and working environment, and appropriate births are helpful to reduce the risk of ASD.(2) Vitamin D deficiency may also be one of the factors affecting autism spectrum disorders.更多还原