【摘要】 在颅脑创伤患者中,大多数属于轻度颅脑创伤,其中部分患者的脑组织在伤后远期会发生神经退行性变,此病的相关病理进展机制至今尚未得到充分阐明,严重影响了其治疗策略的探索和发展。在概括中、重型颅脑创伤后颅内病理改变进程的基础上对比论述已报道的反复轻型颅脑创伤病变进展的机制,并针对上述病理进程的治疗策略的研究进展予以总结,为今后探索该病长期、综合性的治疗方案提供理论依据。更多还原

【Abstract】 Mild traumatic brain injury(mTBI),known as brain concussion,accounts for most of traumatic brain injury(TBI) cases.Neurodegeneration could be observed in brains of some mTBI patients in the long term after injury.The underlying pathological mechanism has not been fully elucidated,which seriously affects the exploration and development of treatment strategies.On the basis of reviewing the procedure of pathological development in injured brain after moderate and severe TBI,this paper contrastively discussed the reported characteristics of pathological changes after repetitive mTBI.In addition,we also summarized the new progress in its therapeutic strategies,which will provide a basis for exploring longterm and comprehensive therapeutic strategies in the future.更多还原