【摘要】 采用单维统计分析结合主成分分析法,研究苦瓜皂苷与南瓜多糖或苦荞黄酮联合作用对高脂血症大鼠糖脂代谢的改善作用。结果表明:苦瓜皂苷和南瓜多糖联合作用对胆固醇(TC)、游离脂肪酸(FFA)、肌酐(CRE)和瘦素(LP)改善作用优于单一提取物(P<0.05);在胆固醇(TC)、肌酐(CRE)和游离脂肪酸(FFA)改善效果方面,苦瓜皂苷和苦荞黄酮联合作用同样显著优于各单一提取物(P<0.05)。PCA分析也证实了联合作用对高脂血症有着更加显著的改善作用,且多种活性成分联合使用还可能是通过作用不同的靶点通路起到增效或协同的作用。更多还原

【Abstract】 The effects of bitter melon(Momordica charantia) saponins, pumpkin(Cucurbita moschata) polysaccharides and buckwheat(Fagopyrum tataricum) flavones on glucose and lipid metabolism in hyperlipidemic rats were studied by singledimensional statistical analysis combined with principal component analysis. The results showed that combined bitter melon saponins and pumpkin polysaccharide significantly improved levels of TC, FFA, CRE and LP compared with that of individual extracts(P<0.05). Bitter melon saponin and buckwheat flavones improved effect of TC, CRE and FFA significantly better than that of single component(P<0.05). PCA analysis also confirmed that the combined effect of active ingredients produced more improvement of glucose and lipid metabolism in hyperlipidemic rats by acting on different target pathways.更多还原