【摘要】 目的:研究男性精子DNA完整性、精子畸形率(SMR)与其配偶自然流产频次的相关性,以此评估是否可以将精子DNA碎片指数(DFI)作为自然流产的独立预测指标。方法:回顾性分析2020年1月至2021年1月粤北人民医院生殖医学中心60例自然流产孕妇的配偶临床资料,根据受检男性精子DFI分为观察组(DFI>30 %,30例)与对照组(DFI≤30 %,30例)。分析两组男性的年龄、畸形精子率与其配偶自然流产频率的相关性。结果:观察组男性的SMR高于对照组、年龄及其配偶自然流产次数均高于对照组,差异均具有统计学意义(P<0.05);女性自然流产次数与其配偶(男性)年龄、SMR、DFI呈正相关(r=0.531、0.742、0.673,P均<0.05)。结论:男性精子DNA是否完整、精子形态是否正常与其配偶发生自然流产的频次密切相关,DFI可作为自然流产的独立预测指标。更多还原

【Abstract】 Objective To study the correlation between male sperm DNA integrity,abnormal sperm rate and the frequency of spontaneous abortion,so as to evaluate whether sperm DNA fragment index (DFI) can be used as an independent predictor of spontaneous abortion.Methods the clinical data of 60 pregnant women with spontaneous abortion in reproductive medicine center of North Guangdong People’s Hospital from January 2020 to January 2021 were analyzed retrospectively.According to the male sperm DNA fragmentation index (DFI),they were divided into observation group (DFI > 30%,30 cases) and control group (DFI ≤ 30%,30 cases).The correlation between age,abnormal sperm rate and the frequency of spontaneous abortion was analyzed.Results The SMR of men in the observation group was higher than that in the control group,and the age and the number of spontaneous abortions of their spouses were higher than those in the control group (P < 0.05);The number of spontaneous abortions in women was positively correlated with the age,SMR and DFI of their spouses (male) (r=0.531,0.742,0.673,all P < 0.05).Conclusion Whether male sperm DNA is complete and whether sperm morphology is normal is closely related to the frequency of spontaneous abortion.DFI can be used as an independent predictor of spontaneous abortion.更多还原