【摘要】 高血压是全世界范围内的高发慢性病之一,且高海拔地区(海拔≥2 500 m)居民高血压发病率高于平原地区。高海拔地区低压低氧、寒冷等地理因素及机体为适应高海拔地区的代偿机制而导致高血压形成机制不同于平原地区,且急性暴露于高海拔地区人群和高海拔地区世居居民的高血压机制也有所区别。目前研究表明,高海拔地区世居居民降压药物治疗效果受高血压形成机制和机体代偿机制的影响,且有效降压药物的循证证据并不多。基于此,本文主要综述了高海拔地区世居居民高血压药物治疗进展,并发现肾素-血管紧张素-醛固酮系统(RASS)阻滞剂相对具有较好的降压效果。更多还原

【Abstract】 Hypertension is one of the chronic diseases, and with high incidence all over the world, and the incidence of hypertension is higher in high altitude area(altitude≥2 500 m) than in plain area. Due to geographical factors such as low pressure, hypoxia and cold in high altitude areas and the compensatory mechanism of the body to adapt, the formation mechanism of hypertension is different from that in plain areas, and it was also different between the population exposed to high altitude sunddenly and the inhabitants. Current studies show that the effect of drugs is influenced by the mechanism of hypertension formation and body compensation, and there is not much evidence of effective drugs. Based on it, this article mainly reviewed the progress of drug treatment of hypertension in inhabitants of high altitude area, and it was found that renin angiotensin aldosterone system(RASS) blockers had better antihypertensive effect.更多还原