【摘要】 目的研究心脏淀粉样变(cardiac amyloidosis,CA)患者心率变异性变化规律及其临床意义。方法选择30例CA住院患者(CA组)与33例健康成人志愿者(对照组)进行24 h动态心电图心率变异性指标比较、分析。结果与对照组比较,CA组的心率变异性指标SDNN、SDNN Index、三角指数、SDANN、r MSSD、p NN50、高频功率(HF)、低频功率(LF)及LF/HF值均有所降低,其中SDNN、SDNN Index、三角指数、SDANN、LF及LF/HF值明显低于对照组(P <0.05)。结论 CA患者心率变异性各指标下降,提示心脏自主神经功能障碍,迷走神经及交感神经活性均减弱,且以交感神经活性减弱为主。更多还原

【Abstract】 Objective To study the change regulation of heart rate variability( HRV) and its clinical significance in patients with cardiac amyloidosis( CA). Methods Thirty CA inpatients( CA group) and 33 healthy adult volunteers( control group) were selected for comparative analysis of HRV indexes recorded by 24-hour ambulatory electrocardiograph. Results Compared with the control group,the HRV indexes of SDNN,SDNN Index,triangle index,SDANN,r MSSD,p NN50,HF,LF,and LF/HF ratio of the CA group are all reduced.Among them,SDNN,SDNN Index,triangle index,SDANN,LF and LF/HF ratio of the CA group are significantly lower than those of the control group( P < 0. 05). Conclusion The decline of HRV indexes in CA patients indicates cardiac autonomic dysfunction. Vagus nerve and sympathetic nerve activities are both weakened,and the latter is dominant.更多还原