【摘要】 目的探讨Kelch样环氧氯丙烷相关蛋白-1、生长分化因子-15在结直肠癌患者中的表达情况以及其与临床分期的相关性。方法收集200例结直肠癌患者(实验组)及200例结直肠息肉患者(结直肠良性病变组),分别比较两组患者Kelch样环氧氯丙烷相关蛋白-1、生长分化因子-15表达情况及其与临床分期间的关系。结果结直肠癌患者Keap1的阳性表达率(80%)及血清中GDF 15表达水平[(1278.53±120.69) ng/l]均显著高于结直肠良性病变组患者Keap1的阳性表达率(25%)及血清中GDF 15表达水平[(759.54±98.99) ng/l],两组间差异有统计学意义(P <0.05);伴随着临床T分期的进展,结直肠癌Keap1阳性表达率却呈逐渐减低的趋势,各分期间差异有统计学意义(P <0.05);而不同N分期间结直肠癌Keap1阳性表达率差异无统计学意义(P> 0.05)。血清中GDF 15的表达水平,则伴随着T、N分期的进展而呈逐渐增高的趋势,各组间差异有统计学意义(P <0.05); Spearman相关分析表明,Keap1与结直肠癌临床T分期有关(γ=0.327,P=0.014);血清中GDF 15表达水平与结直肠癌临床T、N分期均有关(γ=0.457,P=0.002;γ=0.294,P=0.026)。结论 Kelch样环氧氯丙烷相关蛋白-1、生长分化因子-15在结直肠癌患者中表达明显增高,且与淋巴结转移、TNM分期密切相关。更多还原

【Abstract】 Objective To investigate the expression of Kelch-like epichlorohydrin-related protein-1 and growth differentiation factor-15 in patients with colorectal cancer and their correlation with clinical stages. Methods 200 patients with colorectal cancer( experimental group) and 200 patients with colorectal polyps( benign lesion group) were collected. The expressions of Kelch-like epichlorohydrin-1 and growth differentiation factor-15 and their relationship with clinical stages were compared between the 2 groups. Results The positive expression rate of Keap1 in patients with colorectal cancer( 80%) and the expression level of GDF 15 in serum[( 1278. 53 ± 120. 69) ng/l]were significantly higher than the positive expression rate of Keap1 in patients with colorectal benign lesions( 25%) and serum levels. The expression level of GDF 15[( 759. 54 ± 98. 99) ng/l],the difference between the 2 groups was statistically significant( P < 0. 05); with the progress of clinical T staging,the positive expression rate of Keap1 in colorectal cancer showed a gradually decreasing trend. The difference in the period was statistically significant( P < 0.05); while the difference in the positive expression rate of Keap1 in colorectal cancer was not statistically significant( P > 0. 05)during the N-point period. As for the expression level of GDF 15 in serum,it gradually increased with the progress of T and N stages,and the difference between the groups was statistically significant( P < 0. 05); Spearman correlation analysis showed that Keap1 is associated with clinical colorectal cancer T staging is related( γ = 0. 327,P = 0. 014); serum GDF 15 expression level is related to clinical T and N staging of colorectal cancer( γ = 0. 457,P = 0. 002; γ = 0. 294,P = 0. 026). Conclusion The expression of Kelch-like epichlorohydrin-related protein-1 and growth differentiation factor-15 is significantly increased in patients with colorectal cancer,and is closely related to lymph node metastasis and TNM staging.更多还原