【摘要】 原发性肝癌作为世界范围内常见的恶性肿瘤,具有较高的发病率及致死率。由于缺乏理想的诊断及治疗手段,肝癌患者5年生存率较低。最新研究显示,长链非编码RNA在肝癌的发生、发展、转移及侵袭等多种生物学行为中扮演着重要角色并且在肝癌组织中存在表达失调。进一步的研究表明,多种长链非编码RNA在肝癌患者血浆中存在明显的表达失调,表现出成为新兴肿瘤标志物的潜力。本文旨在回顾目前已报道的在肝癌患者血浆中表达失调的lncRNA及其对肝癌的诊断价值。更多还原

【Abstract】 Hepatocellular carcinoma(HCC) is one of the most common cancers worldwide with high morbidity and fatality.Patients with HCC always have a poor prognosis due to difficulty in early diagnosis and efficient treatment.Recent studies have suggested that long non-coding RNAs(lncRNAs) played vital roles in various biological processes involved in HCC,such as initiation, progression, metastasis and invasion.Advanced studies have shown that several well-known lncRNAs are dysregulated in HCC tissue compared to adjacent noncancerous tissue.Furthermore, several lncRNAs, aberrantly expressed in the plasma of HCC patients, have been detected and may become novel biomarkers in the future.In this review, we focused on lncRNAs which have been reported to be dysregulated in the sera of HCC patients and discussed their diagnostic value.更多还原