【摘要】 目的:回顾性分析局部晚期鼻咽癌患者治疗前外周血中乳酸脱氢酶/白蛋白比例（lactate dehydrogenase to albumin ratio,LAR）与患者治疗后预后的相关性。方法:收集2014年06月至2018年12月之间收治入院的296例初治Ⅲ/Ⅳ_a,b期（AJCC第7版分期）鼻咽癌患者为研究对象,采用外周血中LAR中位值3.633为阈值对所有患者进行分层。分析局部晚期鼻咽癌患者治疗前外周血中LAR与总生存（OS）、无局部复发生存（LRFS）和无远处转移生存（DMFS）的相关性。结果:高LAR组（≥3.633）与年龄大（P=0.000）、死亡（P=0.000）相关;Cox风险模型分析显示LAR与局部晚期鼻咽癌患者的OS、LRFS、DMFS三者均存在相关性,LAR越高,预示着更差的OS、LRFS、DMFS。结论:局部晚期鼻咽癌患者治疗前外周血LAR水平是独立的不良预后因素,可用于风险分层及指导辅助治疗。更多还原

【Abstract】 Objective:To evaluate the predictive value of peripheral blood lactate dehydrogenase to albumin ratio（LAR） in patients with locally advanced nasopharyngeal carcinoma（NPC）.Methods:A total of 296 patients with Ⅲ/Ⅳ_a,b（AJCC 7 th edition） nasopharyngeal carcinoma（NPC）,who admitted in hospital between June 2014 to December 2018 were enrolled.We employed a threshold of pretreatment LAR=3.633（median） to stratify patients.The association between pretreatment LAR and curative effect before treatment and its effects on distant metastasis-free survival（DMFS）,local recurrence-free survival（LRFS） and overall survival（OS） were analyzed.Results:High LAR（ ≥3. 633） was associated with advanced age（ P = 0. 000） and deaths（ P = 0. 000）. Cox multivariate regression model showed that high LAR was an independent inferior prognostic factor for OS,LRFS,DMFS. Conclusion: Pretreatment LAR is an independent prognostic factor in locally advanced nasopharyngeal carcinoma and could be used in risk stratification and guiding adjuvant therapy.更多还原