【摘要】 胃肠胰神经内分泌肿瘤(GEP-NENs)较为少见,除少部分功能性肿瘤可分泌激素并引起类癌综合征外,大多数患者症状不典型,早期诊断较为困难,确诊时多伴有远处转移,因此寻找一组对GEP-NENs具有早期诊断价值的血清标志物,对提高诊断及判断预后至关重要。神经内分泌肿瘤(NENs)能够分泌多肽、胺类及蛋白类物质进入血液循环,研究显示检测这些物质水平对早期诊断GEP-NENs有一定价值。这些血清标志物包括嗜铬粒蛋白A(CgA)、神经元特异性烯醇化酶(NSE)、胰多肽(PP)、CgB等。现对它们在GEP-NENs早期诊断中的国内外研究进展进行综述。更多还原

【Abstract】 Gastroenteropancreatic neuroendocrine tumors(GEP-NENs) are relatively rare.Except for a small number of functional tumors that can secrete hormones and cause carcinoid syndrome, most patients have atypical symptoms.Early diagnosis is difficult, and the diagnosis is often accompanied by distant locations metastasis, so finding a set of serum markers with early diagnostic value for GEP-NENs is very important to improve diagnosis and judge prognosis.Neuroendocrine tumors(NENs) can secrete peptides, amines and proteins into the blood circulation, and studies have shown that detecting the levels of these substances has certain value in the early diagnosis of GEP-NENs.These serum markers include chromogranin A(CgA),neuron-specific enolase(NSE),pancreatic polypeptide(PP),CgB,etc.Now the domestic and foreign research progress of them in the early diagnosis of GEP-NENs is reviewed.更多还原