【摘要】 目的探讨西安地区体检人群幽门螺杆菌感染及分型状况,为临床方案制定提供理论依据。方法选取2020年10月～2021年3月在陕西省人民医院进行体检的1 035例受试者作为研究对象,采用免疫印迹法检测Hp抗体及分型。比较不同性别及年龄Hp感染的情况。结果 1 035例研究对象按照Hp抗体分型检测结果分为HpⅠ型感染组、HpⅡ型感染组和对照组。Hp总感染率为54.10%,其中Ⅰ型和Ⅱ型感染率分别为30.43%和23.67%,两者比较差异有统计学意义(χ~2=0.982,P<0.05);男性和女性总感染率分别为52.38%和55.88%,两者差异无统计学意义(χ~2=1.278,P>0.05)。男性Ⅰ型感染率高于Ⅱ型(31.43%vs 20.95%),差异有统计学意义(χ~2=0.992,P<0.05),女性Ⅰ型和Ⅱ型感染率分别为29.41%和26.47%,差异无统计学意义(χ~2=0.587,P>0.05)。按不同年龄段分组分析:18岁以下,31～40岁和41～50岁Ⅰ型感染率高于Ⅱ型,差异均有统计学意义(χ~2=13.445,5.000和4.462,均P<0.05),18～30岁和≥50岁组Ⅰ型和Ⅱ型感染率差异无统计学意义(χ~2=2.019,3.452,2.693和3.167,均P>0.05)。结论西安地区体检人群幽门螺杆菌感染率较高,以Ⅰ型为主,尤其是男性患者,且年龄小于18岁及30～50岁患者更易感,Hp抗体分型为临床制定治疗方案提供理论依据。更多还原

【Abstract】 Objective To investigate the status of Helicobacter pylori(Hp) infection and the subtypes in physical examination population in Xi’an Area, and provide theoretical basis for clinical planning. Methods 1 035 persons who underwent physical examination in Shaanxi Provincial People’s Hospital from October 2020 to March 2021 were selected as the research objects. Hp antibody and typing were detected by Western blot, and to compare the rate of Hp infection in different sex and age. Results According to the results of Hp antibody typing, 1 035 persons were divided into Hp type Ⅰ infection group, Hp type Ⅱ infection group and control group. The total infection rate of Hp in 1 035 cases was 54.10%, of which the infection rates of type Ⅰ and type Ⅱ were 30.43% and 23.67%, respectively. The infection rate of type I was significantly higher than the type Ⅱ(χ~2 = 0.982, P < 0.05). The total infection rate of male and female were 52.38%, 55.88%,respictively. There was no significant difference in the total infection rate between male and female(χ~2 = 1.278, P > 0.05). The infection rate of type Ⅰ(31.43%) was higherthan that of type Ⅱ(20.95%) in male(χ~2 = 0.992, P < 0.05). The infection rates of type Ⅰ and type Ⅱ in women were 29.41% and 26.47% respectively, which was no significant difference(χ~2= 0.587, P>0.05). According to different age groups, the infection rates of type Ⅰ in under 18 years old, 31～40 years old and 41～50 years old were higher than those of type Ⅱ, with significant difference(χ~2 = 13.445, 5.000 and 4.462, P < 0.05). Conclusion The infection rate of Hp in physical examination population in Xi’an was higher, mainly type I, especially male patients, and the patients younger than 18 years and 30～50 years old were more susceptible. Hp antibody typing provides theoretical basis for clinical treatment.更多还原