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宫颈组织免疫组化染色检测P16/Ki67的表达在LSIL和ASC-US中的应用价值
Application Value of Immunohistochemical Staining of Cervical Tissue to Detect the Expression of P16/Ki67 in LSIL and ASC-US
【摘要】 低级别鳞状上皮内病变(low-grade squamous intraepithelial leasion,LSIL)和非典型鳞状细胞(atypical squamous cells of undetermined significance,ASC-US)是宫颈病变的常见类型,临床上主要采用HPV-DNA检测对LSIL和ASCUS进行分流,但该分流方法存在漏诊率高等问题。目前,迫切需要一些生物标记物和检测方法来预测LSIL和ASC-US病例的转归,实现其分流管理。
【Abstract】 Low grade squamous intraepithelial lesion(LSIL) and atypical squamous cells of undetermined significance( ASCUS) are common types of cervical lesion. Clinical determination of LSIL and ASC-US was mainly carried out by HPV-DNA detection, but this triage method has the problem of high rate of missed diagnosis. Nowadays, some biomarkers and detection methods were urgently needed to predict the outcome of LSIL and ASC-US, and achieve its distributive management.
【基金】 国家自然科学基金(NO:81760386);石河子大学大学生研究训练计划资助项目(SRP110)
- 【文献出处】 现代检验医学杂志 ,Journal of Modern Laboratory Medicine , 编辑部邮箱 ,2021年01期
- 【分类号】R737.33;R730.43
- 【被引频次】1
- 【下载频次】290