【摘要】 目的:探讨躁狂症患者同型半胱氨酸(Hcy)测定的临床意义。方法:选取2016年1月—2017年6月收治的躁狂症患者100例作为观察组,选取同期健康体检者40例作为对照组。采用全自动生化分析仪循环酶法测定所有受试者血清Hcy水平,比较两组Hcy水平、治疗前不同躁狂程度患者的Hcy水平,治疗前后躁狂症患者Hcy水平及克拉范森躁狂量表(BRMS)评分,分析治疗前血清Hcy与BRMS评分的相关性。结果:观察组血清Hcy水平显著高于对照组,差异具有统计学意义(P<0.05);轻、中、重度躁狂症患者Hcy水平依次增加,差异具有统计学意义(P<0.05);治疗后躁狂症患者BRMS评分及Hcy水平均明显低于治疗前,差异具有统计学意义(P<0.05)。相关性分析结果显示躁狂症患者血清Hcy水平与BRMS评分呈正相关(r=0.526,P<0.001)。结论:躁狂症患者血清Hcy水平升高,Hcy水平与躁狂症患者BRMS评分呈正相关,Hcy可作为评估躁狂症患者的一个生化检测指标。更多还原

【Abstract】 Objective:To investigate the clinical significance of homocysteine(Hcy) determination in mania patients.Methods:From January 2016 to June 2017,100 patients with mania in hospital were selected as observation group,In the same period,40 healthy patients were selected as control group.The level of serum Hcy of all subjects were measured by circulating enzymatic method of automatic biochemical analyzer.The level of seurm Hcy was compared between two groups,the level of seurm Hcy of patients with different degrees of mania was compared before the treatment.The level of Hcy and the Bech-Rafaelsen Mania Rating Scale(BRMS) of mania patinets were compared before and after treatment.The correlation between serum Hcy and BRMS score before treatment was analyed.Results:The level of serum Hcy of mania group was significantly higher than that of control group(P<0.05).The level of Hcy of mild,moderate and severe mania patients increased in turn,and the difference was statistically significant(P<0.05).The BRMS scores and the level of Hcy of mania patients after treatment were significantly lower than those before treatment(P<0.05).The results of correlation analysis showed a positive correlation between serum Hcy levels and BRMS scores in mania patients(r=0.526,P<0.001).Conclusion:The level of serum Hcy of mania patients is increased,and the level of serum Hcy is positively correlated with the BRMS score of mania patients,Hcy can be used as a biochemical test index to evaluate mania patients.更多还原