【摘要】 目的:探讨莫西沙星联合纤维支气管镜药物灌注对耐多药肺结核患者T细胞亚群、肺功能和肝功能的影响。方法:选取2017年2月～2018年12月期间我院收治的90例耐多药肺结核患者,根据随机数字表法分为对照组（n=45,常规基础治疗）和研究组（n=45,莫西沙星联合纤维支气管镜药物灌注）,比较两组患者痰菌转阴率、病灶吸收率、T细胞亚群、肺功能和肝功能。结果:研究组治疗6个月后的痰菌转阴率为88.89%（40/45）,高于对照组的68.89%（31/45）（P<0.05）。研究组治疗6个月后的病灶吸收率为84.44%（38/45）,高于对照组的64.44%（29/45）（P<0.05）。两组治疗6个月后第1 s用力呼气容积（FEV₁）、用力肺活量（FVC）、每分钟最大通气量（MVV）占预计值百分比、总蛋白（TP）、CD4⁺、CD4⁺/CD8⁺均升高,且研究组高于对照组（P<0.05）;丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、CD8⁺均降低,且研究组低于对照组（P<0.05）。结论:莫西沙星联合纤维支气管镜药物灌注治疗耐多药肺结核,可有效阻止疾病进展,同时在改善患者T细胞亚群、肺功能和肝功能方面效果显著。更多还原

【Abstract】 Objective: To investigate the effect of moxifloxacin combined with bronchofiberscope on T cell subsets, lung function and liver function in Multidrug resistant tuberculosis patients. Methods: 90 Multidrug resistant tuberculosis patients in our hospital from February 2017 to December 2018 were selectd, they were divided into control group（n=45, routine basic treatment） and study group（n=45, moxifloxacin combined with bronchofiberscope drug perfusion） according to the random number table method. The sputum negative rate, focus absorption rate, T cell subsets, lung function and liver function were compared between the two groups. Results: The sputum negative rate of the study group was 88.89%（40/45）, which was higher than 68.89%（31/45） of the control group（P<0.05）. The absorption rate of focus in the study group was 84.44%（38/45）, which was higher than 64.44%（29/45） in the control group（P<0.05）. After 6 months of treatment, forced expiratory volume（FEV₁）, forced vital capacity（FVC）, and maximum ventilation volume per minute（MVV） as a percentage of the predicted value, the total protein（TP）, CD4⁺, CD4⁺/CD8⁺in the first second in the two groups were higher than those of the control group, and the study group were higher than the control group（P<0.05）. Alanine aminotransferase（ALT）, aspartate aminotransferase（AST） and CD8⁺decreased, and the study group was lower than that in the control group（P<0.05）. Conclusion:Moxifloxacin combined with fiberbronchoscopic drug perfusion can effectively prevent the progress of the disease and improve the T cell subsets, lung function and liver function of the patients.更多还原