【摘要】 随着环境污染日益严重,国内外有关环境污染物导致健康风险的毒性机制研究已引起广泛关注。然而,环境污染物对机体肠道菌群结构、功能的改变及其对毒性效应的调控作用研究尚处起步阶段。本综述在归纳近年来国内外人体及模式生物的肠道菌群研究进展的基础上,重点阐述了以重金属污染物、微纳米颗粒污染物、持久性有机污染物以及抗生素为代表的典型环境污染物对肠道菌群结构、组成、数量以及代谢等的影响,总结了肠道菌群在机体毒性效应中潜在调控作用,为后续肠道菌群在环境污染物毒理学效应及人类健康风险方面的系统研究提供理论参考。更多还原

【Abstract】 With the increasingly serious environmental pollution,studies on the toxicological mechanisms of environmental pollutants leading to health risks has caused great concerns. However,the investigation on how environmental pollutants affect the structure and function of the gut microbiota and its regulation of toxic effects is still largely unknown.Based on the characteristics of gut microbiota in the human and animal models,this paper focused on the structure,diversity and composition of gut microbiota altered by typical environmental pollutants including heavy metals,micro-nano particle,persistent organic pollutants and antibiotics. In addition,the potential regulatory role of gut microbiota in the toxicological effects of organisms were summarized. It provided a theoretical basis for subsequent systematic studies on gut microbiota regulated toxicological effects of environmental pollutants and human health risks.更多还原