【摘要】 微小RNA (microRNA, miRNA)是一类由19～24个核苷酸构成的内源性的非编码单链RNA,通过与靶基因完全或不完全结合降解mRNA或抑制mRNA的翻译,在体内起到转录后调控作用,参与多种生理和病理过程。新近报道发现,miR-338-5P在黑色素瘤、消化系统肿瘤、肺癌等各种类型的癌症中异常表达,其通过结合一系列的靶基因来调控细胞增殖、转移、侵袭和凋亡,在不同肿瘤中发挥抑癌或促癌的不同作用,并可能成为癌症诊断的生物标志物和治疗靶点。在其他炎性相关疾病中,比如病理性心肌肥厚、类风湿性关节炎等,也发现mi R-338-5P可以通过靶向不同基因,参与疾病的发生发展。现综述miR-338-5P在肿瘤、肿瘤放化疗以及其他炎性相关疾病中的作用和其在疾病诊断、预后判断等方面的应用,为肿瘤等疾病相关标志物以及更有效的治疗靶点的开发提供新思路。更多还原

【Abstract】 MicroRNA(miRNA) is a class of endogenous non-coding single-stranded RNA composed of 19-24 nucleotides. By completely or partially binding to target mRNAs to degrade mRNA or inhibit protein expression, miRNA plays a role in post-transcriptional expression regulation in vivo and is involved in various physiological and pathological processes. New reports found that miR-338-5 P is abnormally expressed in melanoma, digestive system tumors, lung cancer and other types of cancers, playing diverse roles through the binding to a series of target genes to regulate cell proliferation, metastasis, invasion and apoptosis in the different background as a tumor suppressor or promoter, and may become cancer biomarkers and therapeutic targets. In other inflammatory diseases, such as pathological cardiac hypertrophy and rheumatoid arthritis, miR-338-5 P has also been found to be involved in the occurrence and development of diseases by targeting different genes. The function and application potentials of miR-338-5 P in human diseases, including tumors and other inflammatory diseases, were reviewed to provide new ideas for the development of disease diagnosis, prognostic biomarkers and more effective therapeutic targets.更多还原