【摘要】 目的探讨中国南部地区表观健康人群脂蛋白相关磷脂酶A2(Lp-PLA2)水平分布及其与低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)的相关性。方法选取中国南部地区8家三级甲等医院健康体检者2 318名,检测血清Lp-PLA2及血脂[总胆固醇(TC)、三酰甘油(TG)、LDL-C、高密度脂蛋白胆固醇(HDL-C)]、hs-CRP水平,将所有对象按性别和年龄(<50岁、50～59岁、60～69岁、70～79岁、≥80岁)分别分组。采用Pearson相关分析或Spearman相关分析评估各项目之间的相关性。结果中国南部地区2 318名表观健康者血清Lp-PLA2总体水平为(145.84±43.96)ng/mL,参考区间上限为217.93 ng/mL。女性血清Lp-PLA2水平低于男性(P<0.05)。<50岁组血清Lp-PLA2水平低于50～59岁组、60～69岁组及70～79岁组(P<0.05),与≥80岁组差异无统计学意义(P>0.05);50～59岁组、60～69岁组及70～79岁组之间血清Lp-PLA2水平差异均无统计学意义(P>0.05)。8家医院中,福建医科大学附属协和医院的血清Lp-PLA2检测结果最低,海南省人民医院的检测结果最高,与其他医院比较,差异均有统计学意义(P<0.05)。相关分析结果显示,Lp-PLA2与LDL-C呈正相关(r=0.163,P<0.05),与TC、TG、HDL-C和hs-CRP均无相关性(r值分别为-0.028、0.000、0.001、0.088,P>0.05)。结论初步建立了中国南部地区表观健康人群血清Lp-PLA2的参考区间。更多还原

【Abstract】 Objective To investigate the distribution of lipoprotein-associated phospholipase A2(Lp-PLA2)levels in southern China,and to evaluate the relationship between Lp-PLA2 and low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP). Methods A total of 2 318 serum samples were collected from 8 Grade 3 Class A hospitals in southern China. Lp-PLA2,blood lipids [total cholesterol(TC),triglyceride(TG) and high-density lipoprotein cholesterol(HDL-C)] and hs-CRP levels were determined. All the subjects were classified according to sex and ages(<50 years old,50-59 years old,60-69 years old,70-79 years old and ≥80 years old). Pearson or Spearman correlation analysis was performed to evaluate the correlations between the items. Results The Lp-PLA2 level of 2 318 healthy subjects in southern China was(145.84±43.96) ng/mL,and the upper limit of reference interval was 217.93 ng/mL. The level of serum Lp-PLA2 in females was lower than that in maless(P<0.05). The level of serum Lp-PLA2 in <50 years old group was lower than those in 50-59,60-69 and 70-79 years old groups(P<0.05),and there was no statistical significance compared with that in ≥80 years old group(P>0.05). There was no statistical significance in serum Lp-PLA2 levels among 50-59,60-69 and 70-79 years old groups(P>0.05). Among the 8 hospitals,the level of Lp-PLA2 in the Union Hospital Affiliated to Fujian Medical University was the lowest,while the level of Lp-PLA2 in Hainan Provincial People’s Hospital was the highest,and there was statistical significance compared with the other hospitals(P<0.05). Lp-PLA2 was positively correlated with LDL-C(r=0.163,P<0.05),and there was no correlation with TC,TG,HDL-C and hs-CRP(r values were-0.028,0.000,0.001 and 0.088,P>0.05,respectively). Conclusions The reference interval of LpPLA2 in healthy subjects in southern China has been established preliminarily.更多还原