【摘要】 目的探讨多囊卵巢综合征（PCOS）患者的肠道菌群结构变化与神经肽Y（NPY）的相关性。方法选取2014年1月—2016年6月在上海交通大学附属第一人民医院内分泌科和妇产科就诊的PCOS患者21例设为PCOS组,另外在社区招募健康育龄期女性13例设为对照组。比较两组患者一般资料、性激素、肠道菌群结构和NPY水平的差异,并分析肠道菌群与NPY水平的相关性。结果 PCOS组BMI、腰围、腰臀比、餐后2 h血糖（2hPG）、餐后2 h胰岛素（2hINS）、HbA_1c、TG、黄体生成素（LH）、LH/卵泡刺激素（FSH）、睾酮水平和多毛评分均显著高于对照组（P值均<0.05）,NPY水平显著低于对照组（P<0.001）。血清NPY水平与LH/FSH、睾酮、多毛评分均呈显著负相关（r=-0.420、-0.449、-0.398,P=0.017、0.009、0.022）。NPY与PCOS组中来自霍尔德曼菌属（Holdemanella）、柯林斯菌属（Collinsella）和普氏菌属（Prevotella）的3个操作分类单元（OTU）相对丰度均呈显著正相关（r=0.355、0.490、0.444,P=0.042、0.004、0.010）,与来自毛螺菌科（Lachnospiraceae）和拟杆菌属（Bacteroides）的3个OTU相对丰度呈显著负相关（r=-0.366、-0.456、-0.487,P=0.036、0.008、0.004）。结论 PCOS患者NPY水平降低,且其与肠道菌群结构紊乱密切相关,调节PCOS患者肠道菌群和NPY水平或可为PCOS的临床防治提供新思路。更多还原

【Abstract】 Objective To explore the correlation between structural changes of gut microbiota and serum neuropeptide Y（NPY） level in patients with polycystic ovary syndrome（PCOS）. Methods A total of 21 PCOS patients admitted to the Shanghai General Hospital from January 2014 to June 2016 were enrolled in this study as PCOS group. In addition, 13 healthy women of reproductive age were recruited from communities as control group. General information, sex hormone level, structural features of gut microbiota and NPY level were compared between the two groups. The correlation between gut microbiota and NPY level was analyzed. Results Compared with the women in the control group, PCOS patients had higher levels of body mass index（BMI）, waist, waist-hip ratio, 2-hour postprandial blood glucose（2 hPG）, 2-hour postprandial insulin（2 hINS）, glycosylated hemoglobin A_{1 c}(HbA_{1 c}), triglyceride（TG）, luteinizing hormone（LH）, LH/follicle-stimulating hormone（FSH）, testosterone（T） and hirsutism score（all P<0.05） and lower level of NPY（P<0.001）. The level of NPY was negatively correlated with LH/FSH, T and hirsutism score（r=-0.420,-0.449,-0.398; P=0.017,0.009,0.022）. NPY level was positively correlated with 3 relative abundance of operational taxonomic units（OTUs） from Holdemanella, Collinsella and Prevotella（r=0.355,0.490,0.444; P=0.042,0.004,0.010）, and negatively correlated with 3 relative abundance of OTU from Lachnospiraceae and Bacteroides（r=-0.366,-0.456,-0.487; P=0.036,0.008,0.004）. Conclusion PCOS patients have decreased NPY level, and it is closely related to the dysbiosis of gut microbiota. Regulating gut microbiota and NPY level may provide a new idea for the prevention and treatment of PCOS.更多还原