【摘要】 目的探讨间苯三酚在无痛人工流产中软化宫颈的作用。方法选取2017年9月至2019年2月保定市第一医院收治的102例无痛人工流产患者,简单随机化分为对照组与观察组,各51例。对照组接受杜异合剂(杜冷丁+异丙嗪)无痛人工流产术,观察组在对照组的基础上,于术前15min静脉注射间苯三酚80mg,麻醉起效后实施无痛人工流产术。比较两组的手术时间、术中出血量、杜异合剂用量、宫颈软化优良率、镇痛效果、不良反应发生率。结果两组术中出血量比较差异无统计学意义(P>0.05);观察组手术时间、杜异合剂用量均显著低于对照组(t值分别为8.978、3.174,均P<0.05);观察组宫颈软化优良率(96.08%)显著高于对照组(78.43%)(χ~2=7.141,P<0.05);观察组镇痛效果0级、Ⅰ级占比(50.98%、41.18%)均高于对照组(23.53%、21.57%),Ⅱ级、Ⅲ级占比(5.88%、1.96%)均低于对照组(39.22%、15.69%),经比较差异有统计学意义(U=4.244,P<0.05);观察组不良反应发生率(1.96%)显著低于对照组(15.69%)(χ~2=4.387,P=0.036)。结论间苯三酚应用于无痛人工流产中,可促进宫颈软化,改善宫颈条件,缩短手术时间,提高镇痛效果,减少人工流产综合征的发生。更多还原

【Abstract】 Objective To study effect of phloroglucinol on softening cervix in painless artificial abortion.Methods 102 pregnant women who underwent painless artificial abortion in THe First Baoding Municipal Hospital from September 2017 to February 2019 were selected and divided into observation group and control group in simple randomization method(n=51 in each group).The pregnant women in the control group received painless artificial abortion by dolantin + promethazine.While those pregnant women in the observation group received intravenous injection of 80 mg of phloroglucinol at 15 minutes before operation besides the administration as that in the control group,and painless artificial abortion was performed after the anesthesic effect came about.The operation duration,intraoperative blood loss,dosage of Duyi mixture(dolantin + promethazine),excellent and good rate of cervical softening,analgesic effect and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in intraoperative blood loss between the two groups(P>0.05).The operation duration and the dosage of Duyi mixture in the observation group were significantly lower than those used in the control group(t=8.978 and 3.174 respectively,both P<0.05).The excellent and good rate of cervical softening in the observation group(96.08%) was significantly higher than that in the control group(78.43%)(χ~2=7.141,P<0.05).The proportions of grade 0 and grade Ⅰ of analgesic effect(50.98%,41.18%) in the observation group were higher than those in the control group(23.53%,21.57%),while the proportions of grade Ⅱ and grade Ⅲ of analgesic effect(5.88%,1.96%) were lower than those of the control group(39.22%,15.69%),and the differences were statistically significant(U=4.244,P<0.05).The incidence of adverse reactions in the observation group(1.96%) was significantly lower than that in the control group(15.69%)(χ~2=4.387,P=0.036).Conclusion Administration of phloroglucinol in painless artificial abortion can promote cervical softening,improve cervical conditions,shorten the operation duration,improve the analgesic effect and reduce occurrence of induced abortion syndrome.更多还原